Home  |  Contact

A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 3.3.2.6

Accepted Name
Leukotriene-A(4) hydrolase.
Alternative Name(s)
Leukotriene A(4) hydrolase.
Leukotriene-A4 hydrolase.
LTA-4 hydrolase.
Reaction catalysed
(7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H(2)O <=> (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate
Cofactor(s)
Zn(2+).
Comment(s)
  • A bifunctional zinc metalloprotease that displays both epoxide hydrolase and aminopeptidase activities.
  • It preferentially cleaves tripeptides at an arginyl bond, with dipeptides and tetrapeptides being poorer substrates.
  • It also converts leukotriene A(4) into leukotriene B(4), unlike EC 3.2.2.10 which converts leukotriene A(4) into 5,6-dihydroxy- 7,9,11,14-eicosatetraenoic acid.
Cross-references
PROSITEPDOC00129
BRENDA3.3.2.6
EC2PDB3.3.2.6
ExplorEnz3.3.2.6
PRIAM enzyme-specific profiles3.3.2.6
KEGG Ligand Database for Enzyme Nomenclature3.3.2.6
IUBMB Enzyme Nomenclature3.3.2.6
IntEnz3.3.2.6
MEDLINEFind literature relating to 3.3.2.6
MetaCyc3.3.2.6
UniProtKB/Swiss-Prot
A6SAG8, LKHA4_BOTFB;  Q3SZH7, LKHA4_BOVIN;  P19602, LKHA4_CAVPO;  
Q6S9C8, LKHA4_CHILA;  P09960, LKHA4_HUMAN;  P24527, LKHA4_MOUSE;  
P30349, LKHA4_RAT;  

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.3.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-