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ENZYME entry: EC 3.3.2.6

Accepted Name
leukotriene-A4 hydrolase.
Alternative Name(s)
leukotriene A4 hydrolase.
LTA-4 hydrolase.
Reaction catalysed
H2O + leukotriene A4 <=> leukotriene B4
Comment(s)
  • A bifunctional zinc metalloprotease that displays both epoxide hydrolase and aminopeptidase activities.
  • It preferentially cleaves tripeptides at an arginyl bond, with dipeptides and tetrapeptides being poorer substrates.
  • It also converts leukotriene A4 into leukotriene B4, unlike EC 3.2.2.10 which converts leukotriene A4 into 5,6-dihydroxy- 7,9,11,14-eicosatetraenoic acid.
Cross-references
BRENDA3.3.2.6
EC2PDB3.3.2.6
ExplorEnz3.3.2.6
PRIAM enzyme-specific profiles3.3.2.6
KEGG Ligand Database for Enzyme Nomenclature3.3.2.6
IUBMB Enzyme Nomenclature3.3.2.6
IntEnz3.3.2.6
MEDLINEFind literature relating to 3.3.2.6
MetaCyc3.3.2.6
Rhea expert-curated reactions3.3.2.6
UniProtKB/Swiss-Prot
A6SAG8, LKHA4_BOTFB;  Q3SZH7, LKHA4_BOVIN;  P19602, LKHA4_CAVPO;  
Q6S9C8, LKHA4_CHILA;  P09960, LKHA4_HUMAN;  P24527, LKHA4_MOUSE;  
P30349, LKHA4_RAT;  

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