ENZYME entry: EC 3.4.11.2

Accepted Name

membrane alanyl aminopeptidase

Alternative Name(s)

amino-oligopeptidase

aminopeptidase M

aminopeptidase N

membrane alanine aminopeptidase

membrane aminopeptidase I

microsomal aminopeptidase

particle-bound aminopeptidase

peptidase E

Reaction catalysed

Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide

Comment(s)

Is not activated by heavy metal ions.
Belongs to peptidase family M1.
Formerly EC 3.4.1.2, EC 3.4.3.5 and EC 3.4.13.6.

Cross-references

BRENDA

3.4.11.2

EC2PDB

3.4.11.2

ExplorEnz

3.4.11.2

PRIAM enzyme-specific profiles

3.4.11.2

KEGG Ligand Database for Enzyme Nomenclature

3.4.11.2

IUBMB Enzyme Nomenclature

3.4.11.2

IntEnz

3.4.11.2

MEDLINE

Find literature relating to 3.4.11.2

MetaCyc

3.4.11.2

Rhea expert-curated reactions

3.4.11.2

UniProtKB/Swiss-Prot

Q10736, AMPN_ACEPA	Q7Q2T8, AMPN_ANOGA	P79098, AMPN_BOVIN
P79143, AMPN_CANLF	P37893, AMPN_CAUVC	P04825, AMPN_ECOLI
P79171, AMPN_FELCA	Q10737, AMPN_HAECO	P45274, AMPN_HAEIN
P81731, AMPN_HELAM	P15144, AMPN_HUMAN	P37896, AMPN_LACDL
Q10730, AMPN_LACHE	Q9CIQ1, AMPN_LACLA	P0C2T8, AMPN_LACLC
Q48656, AMPN_LACLL	A2RI32, AMPN_LACLM	P91885, AMPN_MANSE
P97449, AMPN_MOUSE	P15145, AMPN_PIG	P91887, AMPN_PLUXY
P15541, AMPN_RABIT	P15684, AMPN_RAT	Q11010, AMPN_STRLI
Q6Z6L4, APM1A_ORYSJ	Q0J5V5, APM1B_ORYSJ	Q0J2B5, APM1C_ORYSJ
Q6K4E7, APM1D_ORYSJ	Q8VZH2, APM1_ARATH

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