ID   3.4.11.27
DE   archaeal arginyl aminopeptidase.
CA   an N-terminal L-arginyl-L-aminoacyl-[protein] + H2O = an N-terminal
CA   L-alpha-aminoacyl-[protein] + L-arginine.
CC   -!- The enzyme from the archaeon Pyrococcus horikoshii OT3 is
CC       thermostable.
CC   -!- In that enzyme Cys(100) is the nucleophile responsible for the
CC       proteolytic activity, while Tyr(120) regulates the catalytic
CC       conformation of Cys(100) through a hydrogen bond, thereby affecting
CC       enzyme activity.
CC   -!- The activity with L-Arginine is 90-300 times higher than with other
CC       N-terminal amino acids.
CC   -!- The enzyme shows low endopeptidase activity.
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