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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 3.4.11.5

Accepted Name
Prolyl aminopeptidase.
Alternative Name(s)
Cytosol aminopeptidase V.
Pro-X aminopeptidase.
Proline aminopeptidase.
Proline iminopeptidase.
Reaction catalysed
Release of N-terminal proline from a peptide
Cofactor(s)
Mn(2+).
Comment(s)
  • Present in the cytosol of mammalian and microbial cells.
  • In contrast to the mammalian form, the bacterial form of the enzyme hydrolyzes both polyproline and prolyl-2-naphthylamide.
  • The mammalian enzyme, which is not specific for prolyl bonds, is possibly identical with EC 3.4.11.1.
  • Belongs to peptidase family S33.
  • Formerly EC 3.4.1.4.
Cross-references
PROSITEPDOC00548
BRENDA3.4.11.5
EC2PDB3.4.11.5
ExplorEnz3.4.11.5
PRIAM enzyme-specific profiles3.4.11.5
KEGG Ligand Database for Enzyme Nomenclature3.4.11.5
IUBMB Enzyme Nomenclature3.4.11.5
IntEnz3.4.11.5
MEDLINEFind literature relating to 3.4.11.5
MetaCyc3.4.11.5
UniProtKB/Swiss-Prot
P30184, AMPL1_ARATH;  Q2QSB9, AMPL1_ORYSJ;  Q10712, AMPL1_SOLLC;  
Q944P7, AMPL2_ARATH;  Q6K669, AMPL2_ORYSJ;  Q42876, AMPL2_SOLLC;  
Q8RX72, AMPL3_ARATH;  P00727, AMPL_BOVIN;  Q5V9F0, AMPL_DICDI;  
Q8SQZ7, AMPL_ENCCU;  P28838, AMPL_HUMAN;  P86249, AMPL_MESAU;  
Q9CPY7, AMPL_MOUSE;  P28839, AMPL_PIG;  Q68FS4, AMPL_RAT;  
P31427, AMPL_SOLTU;  Q5XGB9, AMPL_XENTR;  W3XA95, PFMAB_PESFW;  
P46547, PIP_AERSO;  P93732, PIP_ARATH;  P46541, PIP_BACCO;  
C0ZKI1, PIP_BREBN;  C7PDD8, PIP_CHIPD;  A5I3F5, PIP_CLOBH;  
O05420, PIP_ELIME;  A5FIF5, PIP_FLAJ1;  Q5FMT1, PIP_LACAC;  
Q03NE0, PIP_LACBA;  D5H0J3, PIP_LACCS;  Q1G8L9, PIP_LACDA;  
P46544, PIP_LACDE;  P46542, PIP_LACDL;  A8YWL3, PIP_LACH4;  
P52278, PIP_LACHE;  Q890D8, PIP_LACPL;  C7TMK0, PIP_LACRL;  
O83041, PIP_LEPBY;  P47266, PIP_MYCGE;  P75092, PIP_MYCPN;  
P42786, PIP_NEIGO;  Q9JUV1, PIP_NEIMA;  Q9JZR6, PIP_NEIMB;  
Q184M8, PIP_PEPD6;  O32449, PIP_SERMA;  Q9S2L4, PIP_STRCO;  
Q97UA2, PIP_SULSO;  P96084, PIP_THEAC;  Q97A76, PIP_THEVO;  
P52279, PIP_XANCI;  Q9PD69, PIP_XYLFA;  Q87DF8, PIP_XYLFT;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.11.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-