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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 3.4.11.9

Accepted Name
Xaa-Pro aminopeptidase.
Alternative Name(s)
Aminoacylproline aminopeptidase.
Aminopeptidase P.
Proline aminopeptidase.
X-Pro aminopeptidase.
Reaction catalysed
Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide
Cofactor(s)
Cobalt cation or Mn(2+).
Comment(s)
  • Generally membrane bound enzyme present in both mammalian and bacterial cells.
  • Belongs to peptidase family M24B.
Cross-references
PROSITEPDOC00417
BRENDA3.4.11.9
EC2PDB3.4.11.9
ExplorEnz3.4.11.9
PRIAM enzyme-specific profiles3.4.11.9
KEGG Ligand Database for Enzyme Nomenclature3.4.11.9
IUBMB Enzyme Nomenclature3.4.11.9
IntEnz3.4.11.9
MEDLINEFind literature relating to 3.4.11.9
MetaCyc3.4.11.9
UniProtKB/Swiss-Prot
C0NDZ7, AMPP1_AJECG;  C6HSY3, AMPP1_AJECH;  A6R035, AMPP1_AJECN;  
C5GXZ9, AMPP1_AJEDR;  F4JQH3, AMPP1_ARATH;  D4ARJ9, AMPP1_ARTBC;  
E4USI8, AMPP1_ARTGP;  C5FHR9, AMPP1_ARTOC;  A1CAQ1, AMPP1_ASPCL;  
B0Y3V7, AMPP1_ASPFC;  B8NEI6, AMPP1_ASPFN;  Q4WUD3, AMPP1_ASPFU;  
A2QGR5, AMPP1_ASPNC;  Q2U7S5, AMPP1_ASPOR;  Q0CDB3, AMPP1_ASPTN;  
C5K105, AMPP1_BLAGS;  A6RK67, AMPP1_BOTFB;  Q2H8T2, AMPP1_CHAGB;  
C5P7J2, AMPP1_COCP7;  E9CTR7, AMPP1_COCPS;  E3QCU0, AMPP1_COLGM;  
A8P5H7, AMPP1_COPC7;  Q5AVF0, AMPP1_EMENI;  B0DZL3, AMPP1_LACBS;  
E5ABQ8, AMPP1_LEPMJ;  A4RF35, AMPP1_MAGO7;  E9E9B2, AMPP1_METAQ;  
E9EUE6, AMPP1_METRA;  C7Z9Z7, AMPP1_NECH7;  A1DF27, AMPP1_NEOFI;  
Q7RYL6, AMPP1_NEUCR;  C1H978, AMPP1_PARBA;  C1GEY4, AMPP1_PARBD;  
C0SCV1, AMPP1_PARBP;  B6HQC9, AMPP1_PENRW;  Q0UFY4, AMPP1_PHANO;  
B2AWV6, AMPP1_PODAN;  B2VUU7, AMPP1_PYRTR;  E3S7K9, AMPP1_PYRTT;  
A7E4T8, AMPP1_SCLS1;  D1ZKF3, AMPP1_SORMK;  P0A3Z1, AMPP1_STRCO;  
P0A3Z2, AMPP1_STRLI;  B6QG01, AMPP1_TALMQ;  B8M9W2, AMPP1_TALSN;  
D4D891, AMPP1_TRIVH;  D5GAC6, AMPP1_TUBMM;  C9SR45, AMPP1_VERA1;  
C0NF18, AMPP2_AJECG;  C6HNY5, AMPP2_AJECH;  A6QYF6, AMPP2_AJECN;  
C5GKT2, AMPP2_AJEDR;  Q8RY11, AMPP2_ARATH;  D4B0B2, AMPP2_ARTBC;  
E4V1Q7, AMPP2_ARTGP;  C5FUV0, AMPP2_ARTOC;  A1CNW6, AMPP2_ASPCL;  
B0XN37, AMPP2_ASPFC;  B8MZI5, AMPP2_ASPFN;  Q4WRV9, AMPP2_ASPFU;  
A2QAW7, AMPP2_ASPNC;  Q2UQH9, AMPP2_ASPOR;  Q0CZM6, AMPP2_ASPTN;  
C5K0R2, AMPP2_BLAGS;  A6SL16, AMPP2_BOTFB;  Q2HA12, AMPP2_CHAGB;  
C5PAH2, AMPP2_COCP7;  E9CY14, AMPP2_COCPS;  E3Q897, AMPP2_COLGM;  
Q5BF48, AMPP2_EMENI;  A4RQ11, AMPP2_MAGO7;  E9E2J4, AMPP2_METAQ;  
E9F9J8, AMPP2_METRA;  C7Z837, AMPP2_NECH7;  A1D1S6, AMPP2_NEOFI;  
A7UWH7, AMPP2_NEUCR;  C1H3X3, AMPP2_PARBA;  C1GHS9, AMPP2_PARBD;  
C0SDW6, AMPP2_PARBP;  B6HAN0, AMPP2_PENRW;  Q0V147, AMPP2_PHANO;  
B2AW39, AMPP2_PODAN;  B2WKR4, AMPP2_PYRTR;  E3RNJ5, AMPP2_PYRTT;  
A7ENP9, AMPP2_SCLS1;  D1ZQL9, AMPP2_SORMK;  P0A3Z3, AMPP2_STRCO;  
P0A3Z4, AMPP2_STRLI;  B6QAW7, AMPP2_TALMQ;  B8M2W9, AMPP2_TALSN;  
D4D6B8, AMPP2_TRIVH;  D5GHP2, AMPP2_TUBMM;  C4JY72, AMPP2_UNCRE;  
C9SDK8, AMPP2_VERA1;  C0NIF0, AMPP3_AJECG;  C6H7R7, AMPP3_AJECH;  
C5G874, AMPP3_AJEDR;  A1CSI0, AMPP3_ASPCL;  B0XW47, AMPP3_ASPFC;  
B8NC10, AMPP3_ASPFN;  Q4X267, AMPP3_ASPFU;  A2QKF6, AMPP3_ASPNC;  
Q0CFZ0, AMPP3_ASPTN;  C5JQ04, AMPP3_BLAGS;  A6SDE9, AMPP3_BOTFB;  
C5PHM7, AMPP3_COCP7;  E9DDK8, AMPP3_COCPS;  E3QYP0, AMPP3_COLGM;  
Q96WX8, AMPP3_EMENI;  E4ZHV7, AMPP3_LEPMJ;  A4RAE9, AMPP3_MAGO7;  
E9DV56, AMPP3_METAQ;  E9EK74, AMPP3_METRA;  C7YVN8, AMPP3_NECH7;  
A1DG66, AMPP3_NEOFI;  C1H9Q9, AMPP3_PARBA;  C1GD57, AMPP3_PARBD;  
C0SHQ0, AMPP3_PARBP;  B6H2M0, AMPP3_PENRW;  Q0U6G5, AMPP3_PHANO;  
B2AFW1, AMPP3_PODAN;  B2WMQ2, AMPP3_PYRTR;  E3S6N7, AMPP3_PYRTT;  
A7EUB3, AMPP3_SCLS1;  D1ZBF6, AMPP3_SORMK;  B6Q8T5, AMPP3_TALMQ;  
B8M0Z4, AMPP3_TALSN;  C4JF09, AMPP3_UNCRE;  C9SEV5, AMPP3_VERA1;  
P15034, AMPP_ECOLI;  P44881, AMPP_HAEIN;  P47566, AMPP_MYCGE;  
P75313, AMPP_MYCPN;  Q07825, FRA1_YEAST;  Q1JPJ2, XPP1_BOVIN;  
Q54G06, XPP1_DICDI;  Q9NQW7, XPP1_HUMAN;  Q6P1B1, XPP1_MOUSE;  
O54975, XPP1_RAT;  O43895, XPP2_HUMAN;  B1AVD1, XPP2_MOUSE;  
Q95333, XPP2_PIG;  Q99MA2, XPP2_RAT;  Q54T46, XPP3_DICDI;  
Q9NQH7, XPP3_HUMAN;  B7ZMP1, XPP3_MOUSE;  Q5R9W8, XPP3_PONAB;  
B5DEQ3, XPP3_RAT;  O44750, XPP_CAEEL;  Q9VJG0, XPP_DROME;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.11.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-