ENZYME entry: EC 3.4.13.18

Accepted Name

cytosol non-specific dipeptidase

Alternative Name(s)

glycyl-glycine dipeptidase

glycyl-leucine dipeptidase

N(2)-beta-alanylarginine dipeptidase

peptidase A

prolinase

prolyl dipeptidase

prolylglycine dipeptidase

Pro-X dipeptidase

Reaction catalysed

Hydrolysis of dipeptides, preferentially hydrophobic dipeptides including prolyl amino acids

Comment(s)

Broad specificity, varying somewhat with source species.
Activated and stabilized by dithiothreitol and manganese.
Inhibited by bestatin and leucine.
Belongs to peptidase family M20.
Formerly EC 3.4.3.1, EC 3.4.3.2, EC 3.4.3.3, EC 3.4.3.6, EC 3.4.13.1, EC 3.4.13.2, EC 3.4.13.3, EC 3.4.13.8, EC 3.4.13.11, EC 3.4.13.13 and EC 3.4.13.15.

Cross-references

BRENDA

EC2PDB

ExplorEnz

PRIAM enzyme-specific profiles

KEGG Ligand Database for Enzyme Nomenclature

IUBMB Enzyme Nomenclature

IntEnz

MEDLINE

MetaCyc

Rhea expert-curated reactions

UniProtKB/Swiss-Prot

All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.

All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.13.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-