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ENZYME entry: EC 3.4.14.4

Accepted Name
Dipeptidyl-peptidase III.
Alternative Name(s)
Dipeptidyl aminopeptidase III.
Dipeptidyl arylamidase III.
DPP III.
Enkephalinase B.
Red cell angiotensinase.
Reaction catalysed
Release of an N-terminal dipeptide from a peptide comprising four or more residues, with broad specificity. Also acts on dipeptidyl 2-naphthylamides
Comment(s)
  • A cytosolic peptidase that is active at neutral pH.
  • It has broad activity on peptides, although it is highly selective for Arg-Arg-2-naphthylamide, at pH 9.2.
  • Active in the hydrolysis of enkephalins.
  • Belongs to peptidase family M49.
Cross-references
BRENDA3.4.14.4
EC2PDB3.4.14.4
ExplorEnz3.4.14.4
PRIAM enzyme-specific profiles3.4.14.4
KEGG Ligand Database for Enzyme Nomenclature3.4.14.4
IUBMB Enzyme Nomenclature3.4.14.4
IntEnz3.4.14.4
MEDLINEFind literature relating to 3.4.14.4
MetaCyc3.4.14.4
Rhea expert-curated reactions3.4.14.4
UniProtKB/Swiss-Prot
P83681, DPP3_BLACR;  Q557H1, DPP3_DICDI;  Q9VHR8, DPP3_DROME;  
Q9NY33, DPP3_HUMAN;  Q99KK7, DPP3_MOUSE;  A7RZW4, DPP3_NEMVE;  
O55096, DPP3_RAT;  Q08225, DPP3_YEAST;  

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