ENZYME entry: EC 3.4.15.1
Accepted Name |
peptidyl-dipeptidase A.
|
Alternative Name(s) |
ACE. |
angiotensin I-converting enzyme. |
carboxycathepsin. |
dipeptidyl carboxypeptidase I. |
kininase II. |
peptidase P. |
peptidyl dipeptidase I. |
Reaction catalysed |
Release of a C-terminal dipeptide, oligopeptide-|-Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of angiotensin I to angiotensin II, with increase in vasoconstrictor activity, but no action on angiotensin II |
Comment(s) |
- Cl(-)-dependent.
- A glycoprotein that is generally membrane-bound.
- Active at neutral pH.
- Only single dipeptides are released from angiotensin I and bradykinin
because of the lack of activity on bonds involving proline.
- Belongs to peptidase family M2.
|
Cross-references |
BRENDA | 3.4.15.1 |
EC2PDB | 3.4.15.1 |
ExplorEnz | 3.4.15.1 |
PRIAM enzyme-specific profiles | 3.4.15.1 |
KEGG Ligand Database for Enzyme Nomenclature | 3.4.15.1 |
IUBMB Enzyme Nomenclature | 3.4.15.1 |
IntEnz | 3.4.15.1 |
MEDLINE | Find literature relating to 3.4.15.1 |
MetaCyc | 3.4.15.1 |
Rhea expert-curated reactions | 3.4.15.1 |
UniProtKB/Swiss-Prot |
Q9VLJ6, ACER_DROME; | P12820, ACE_BOVIN; | Q10751, ACE_CHICK; |
Q10714, ACE_DROME; | Q10715, ACE_HAEIX; | P12821, ACE_HUMAN; |
Q50JE5, ACE_MESAU; | P09470, ACE_MOUSE; | Q9GLN7, ACE_PANTR; |
F1RRW5, ACE_PIG; | P12822, ACE_RABIT; | P47820, ACE_RAT; |
Q6Q4G4, ACE_THETS; |
|
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