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ENZYME

ENZYME entry: EC 3.4.15.1

Accepted Name
peptidyl-dipeptidase A
Alternative Name(s)
ACE
angiotensin I-converting enzyme
carboxycathepsin
dipeptidyl carboxypeptidase I
kininase II
peptidase P
peptidyl dipeptidase I
Reaction catalysed
Release of a C-terminal dipeptide, oligopeptide-|-Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of angiotensin I to angiotensin II, with increase in vasoconstrictor activity, but no action on angiotensin II
Comment(s)
  • Cl(-)-dependent.
  • A glycoprotein that is generally membrane-bound.
  • Active at neutral pH.
  • Only single dipeptides are released from angiotensin I and bradykinin because of the lack of activity on bonds involving proline.
  • Belongs to peptidase family M2.
Cross-references
BRENDA3.4.15.1
EC2PDB3.4.15.1
ExplorEnz3.4.15.1
PRIAM enzyme-specific profiles3.4.15.1
KEGG Ligand Database for Enzyme Nomenclature3.4.15.1
IUBMB Enzyme Nomenclature3.4.15.1
IntEnz3.4.15.1
MEDLINEFind literature relating to 3.4.15.1
MetaCyc3.4.15.1
Rhea expert-curated reactions3.4.15.1
UniProtKB/Swiss-Prot
Q9VLJ6, ACER_DROMEP12820, ACE_BOVINQ10751, ACE_CHICK
Q10714, ACE_DROMEQ10715, ACE_HAEIXP12821, ACE_HUMAN
Q50JE5, ACE_MESAUP09470, ACE_MOUSEQ9GLN7, ACE_PANTR
F1RRW5, ACE_PIGP12822, ACE_RABITP47820, ACE_RAT
Q6Q4G4, ACE_THETS

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