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ENZYME entry: EC 3.4.15.1

Accepted Name
Peptidyl-dipeptidase A.
Alternative Name(s)
ACE.
Angiotensin I-converting enzyme.
Carboxycathepsin.
Dipeptidyl carboxypeptidase I.
Kininase II.
Peptidase P.
Peptidyl dipeptidase I.
Reaction catalysed
Release of a C-terminal dipeptide, oligopeptide-|-Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of angiotensin I to angiotensin II, with increase in vasoconstrictor activity, but no action on angiotensin II
Cofactor(s)
Zn(2+).
Comment(s)
  • Cl(-)-dependent.
  • A glycoprotein that is generally membrane-bound.
  • Active at neutral pH.
  • Only single dipeptides are released from angiotensin I and bradykinin because of the lack of activity on bonds involving proline.
  • Belongs to peptidase family M2.
Cross-references
PROSITEPDOC00129
BRENDA3.4.15.1
EC2PDB3.4.15.1
ExplorEnz3.4.15.1
PRIAM enzyme-specific profiles3.4.15.1
KEGG Ligand Database for Enzyme Nomenclature3.4.15.1
IUBMB Enzyme Nomenclature3.4.15.1
IntEnz3.4.15.1
MEDLINEFind literature relating to 3.4.15.1
MetaCyc3.4.15.1
Rhea expert-curated reactions3.4.15.1
UniProtKB/Swiss-Prot
Q9VLJ6, ACER_DROME;  P12820, ACE_BOVIN;  Q10751, ACE_CHICK;  
Q10714, ACE_DROME;  Q10715, ACE_HAEIX;  P12821, ACE_HUMAN;  
Q50JE5, ACE_MESAU;  P09470, ACE_MOUSE;  Q9GLN7, ACE_PANTR;  
P12822, ACE_RABIT;  P47820, ACE_RAT;  Q6Q4G4, ACE_THETS;  

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