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ENZYME

ENZYME entry: EC 3.4.16.4

Accepted Name
serine-type D-Ala-D-Ala carboxypeptidase
Alternative Name(s)
D-alanyl-D-alanine carboxypeptidase
DD-peptidase
DD-transpeptidase
Reaction catalysed
Preferential cleavage: (Ac)2-L-Lys-D-Ala-|-D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine
Comment(s)
  • A group of bacterial enzymes, membrane-bound.
  • Inhibited by beta-lactam antibiotics, which acylate the active site serine in the enzyme.
  • Distinct from EC 3.4.17.14.
  • Belongs to peptidase families S11, S12 and S13.
Cross-references
BRENDA3.4.16.4
EC2PDB3.4.16.4
ExplorEnz3.4.16.4
PRIAM enzyme-specific profiles3.4.16.4
KEGG Ligand Database for Enzyme Nomenclature3.4.16.4
IUBMB Enzyme Nomenclature3.4.16.4
IntEnz3.4.16.4
MEDLINEFind literature relating to 3.4.16.4
MetaCyc3.4.16.4
Rhea expert-curated reactions3.4.16.4
UniProtKB/Swiss-Prot
P08750, DACA_BACSUP0AEB4, DACA_ECO57P0AEB3, DACA_ECOL6
P0AEB2, DACA_ECOLIQ05523, DACA_GEOSEP44466, DACA_HAEIN
P35150, DACB_BACSUP24228, DACB_ECOLIP45161, DACB_HAEIN
P39844, DACC_BACSUP08506, DACC_ECOLIP33013, DACD_ECOLI
P37604, DACD_SALTYP38422, DACF_BACSUP39042, DACX_STRSK
P39045, DAC_ACTSPP15555, DAC_STRSRQ9I1K1, FTSI2_PSEAE
A2CI41, FTSIH_CHLATQ9MUV9, FTSIH_MESVIQ9TL36, FTSIH_NEPOL
P57317, FTSI_BUCAIO85297, FTSI_BUCAPQ89AQ0, FTSI_BUCBP
B8H0A0, FTSI_CAUVNP0AD69, FTSI_ECO57P0AD68, FTSI_ECOLI
P45059, FTSI_HAEING3XD46, FTSI_PSEAEP0AD67, MRDA_ECO57
P0AD66, MRDA_ECOL6P0AD65, MRDA_ECOLIP44469, MRDA_HAEIN
E1WGF1, MRDA_SALTSP0CL14, MRDA_SALTYA0R7G2, PBP1A_MYCS2
P71707, PBP1A_MYCTUP54488, PBP2A_BACSUA0A0H2ZMF9, PBP2A_STRP2
Q8DNB6, PBP2A_STRR6Q07868, PBP2B_BACSUP16873, PBP2_NEIFL
P08149, PBP2_NEIGOP0A0U8, PBP2_NEIMAP0A0U9, PBP2_NEIMB
O66874, PBPA_AQUAEP39793, PBPA_BACSUQ97GR5, PBPA_CLOAB
A7FY32, PBPA_CLOB1A5I6G4, PBPA_CLOBHA7GHV1, PBPA_CLOBL
A0PZT1, PBPA_CLONNQ0TNZ8, PBPA_CLOP1Q8XJ01, PBPA_CLOPE
Q0SRL7, PBPA_CLOPSQ891X1, PBPA_CLOTEP02918, PBPA_ECOLI
P31776, PBPA_HAEINA0QNG3, PBPA_MYCS2P9WKD0, PBPA_MYCTO
P9WKD1, PBPA_MYCTUO86088, PBPA_NEICIO87626, PBPA_NEIFL
Q5FAC7, PBPA_NEIG1O05131, PBPA_NEIGOO87579, PBPA_NEILA
P0A0Z5, PBPA_NEIMAP0A0Z6, PBPA_NEIMBQ07806, PBPA_PSEAE
Q1RKC5, PBPA_RICBRQ92G78, PBPA_RICCNQ4UK08, PBPA_RICFE
Q9ZCE9, PBPA_RICPRQ68VU2, PBPA_RICTYQ00573, PBPA_STROR
Q04707, PBPA_STRPNQ8DR59, PBPA_STRR6Q9KNU5, PBPA_VIBCH
Q9PGD4, PBPA_XYLFAQ87AW7, PBPA_XYLFTP57296, PBPB_BUCAI
Q89AR2, PBPB_BUCBPP02919, PBPB_ECOLIP45345, PBPB_HAEIN
Q9KUC0, PBPB_VIBCHP42971, PBPC_BACSUP40750, PBPD_BACSU
P38050, PBPF_BACSUP70997, PBPG_BACSUQ796K8, PBPH_BACSU
O32032, PBPI_BACSUQ86I79, PSCA_DICDIQ03524, SP5D_BACSU
Q8XBJ0, YFEW_ECO57P77619, YFEW_ECOLIB5F0K5, YFEW_SALA4
Q57LN2, YFEW_SALCHB5FQG8, YFEW_SALDCB5R4I5, YFEW_SALEP
B5RCU8, YFEW_SALG2B4TD53, YFEW_SALHSB4T0K5, YFEW_SALNS
Q5PCQ2, YFEW_SALPAA9N307, YFEW_SALPBC0PZ64, YFEW_SALPC
B5BB26, YFEW_SALPKB4TR50, YFEW_SALSVQ8Z4S7, YFEW_SALTI
Q8ZN80, YFEW_SALTY

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