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ENZYME entry: EC 3.4.16.4

Accepted Name
Serine-type D-Ala-D-Ala carboxypeptidase.
Alternative Name(s)
D-alanyl-D-alanine carboxypeptidase.
DD-peptidase.
DD-transpeptidase.
Reaction catalysed
Preferential cleavage: (Ac)(2)-L-Lys-D-Ala-|-D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine
Comment(s)
  • A group of bacterial enzymes, membrane-bound.
  • Inhibited by beta-lactam antibiotics, which acylate the active site serine in the enzyme.
  • Distinct from EC 3.4.17.14.
  • Belongs to peptidase families S11, S12 and S13.
Cross-references
BRENDA3.4.16.4
EC2PDB3.4.16.4
ExplorEnz3.4.16.4
PRIAM enzyme-specific profiles3.4.16.4
KEGG Ligand Database for Enzyme Nomenclature3.4.16.4
IUBMB Enzyme Nomenclature3.4.16.4
IntEnz3.4.16.4
MEDLINEFind literature relating to 3.4.16.4
MetaCyc3.4.16.4
Rhea expert-curated reactions3.4.16.4
UniProtKB/Swiss-Prot
P08750, DACA_BACSU;  P0AEB4, DACA_ECO57;  P0AEB3, DACA_ECOL6;  
P0AEB2, DACA_ECOLI;  Q05523, DACA_GEOSE;  P44466, DACA_HAEIN;  
P35150, DACB_BACSU;  P24228, DACB_ECOLI;  P45161, DACB_HAEIN;  
P39844, DACC_BACSU;  P08506, DACC_ECOLI;  P33013, DACD_ECOLI;  
P37604, DACD_SALTY;  P38422, DACF_BACSU;  P39042, DACX_STRSK;  
P39045, DAC_ACTSP;  P15555, DAC_STRSR;  Q9I1K1, FTSI2_PSEAE;  
A2CI41, FTSIH_CHLAT;  Q9MUV9, FTSIH_MESVI;  Q9TL36, FTSIH_NEPOL;  
P57317, FTSI_BUCAI;  O85297, FTSI_BUCAP;  Q89AQ0, FTSI_BUCBP;  
B8H0A0, FTSI_CAUVN;  P0AD69, FTSI_ECO57;  P0AD68, FTSI_ECOLI;  
P45059, FTSI_HAEIN;  G3XD46, FTSI_PSEAE;  P0AD67, MRDA_ECO57;  
P0AD66, MRDA_ECOL6;  P0AD65, MRDA_ECOLI;  P44469, MRDA_HAEIN;  
E1WGF1, MRDA_SALTS;  P0CL14, MRDA_SALTY;  A0R7G2, PBP1A_MYCS2;  
P71707, PBP1A_MYCTU;  P54488, PBP2A_BACSU;  A0A0H2ZMF9, PBP2A_STRP2;  
Q8DNB6, PBP2A_STRR6;  Q07868, PBP2B_BACSU;  P16873, PBP2_NEIFL;  
P08149, PBP2_NEIGO;  P0A0U8, PBP2_NEIMA;  P0A0U9, PBP2_NEIMB;  
O66874, PBPA_AQUAE;  P39793, PBPA_BACSU;  Q97GR5, PBPA_CLOAB;  
A7FY32, PBPA_CLOB1;  A5I6G4, PBPA_CLOBH;  A7GHV1, PBPA_CLOBL;  
A0PZT1, PBPA_CLONN;  Q0TNZ8, PBPA_CLOP1;  Q8XJ01, PBPA_CLOPE;  
Q0SRL7, PBPA_CLOPS;  Q891X1, PBPA_CLOTE;  P02918, PBPA_ECOLI;  
P31776, PBPA_HAEIN;  A0QNG3, PBPA_MYCS2;  P9WKD0, PBPA_MYCTO;  
P9WKD1, PBPA_MYCTU;  O86088, PBPA_NEICI;  O87626, PBPA_NEIFL;  
Q5FAC7, PBPA_NEIG1;  O05131, PBPA_NEIGO;  O87579, PBPA_NEILA;  
P0A0Z5, PBPA_NEIMA;  P0A0Z6, PBPA_NEIMB;  Q07806, PBPA_PSEAE;  
Q1RKC5, PBPA_RICBR;  Q92G78, PBPA_RICCN;  Q4UK08, PBPA_RICFE;  
Q9ZCE9, PBPA_RICPR;  Q68VU2, PBPA_RICTY;  Q00573, PBPA_STROR;  
Q04707, PBPA_STRPN;  Q8DR59, PBPA_STRR6;  Q9KNU5, PBPA_VIBCH;  
Q9PGD4, PBPA_XYLFA;  Q87AW7, PBPA_XYLFT;  P57296, PBPB_BUCAI;  
Q89AR2, PBPB_BUCBP;  P02919, PBPB_ECOLI;  P45345, PBPB_HAEIN;  
Q9KUC0, PBPB_VIBCH;  P42971, PBPC_BACSU;  P40750, PBPD_BACSU;  
P38050, PBPF_BACSU;  P70997, PBPG_BACSU;  Q796K8, PBPH_BACSU;  
O32032, PBPI_BACSU;  Q86I79, PSCA_DICDI;  Q03524, SP5D_BACSU;  
Q8XBJ0, YFEW_ECO57;  P77619, YFEW_ECOLI;  B5F0K5, YFEW_SALA4;  
Q57LN2, YFEW_SALCH;  B5FQG8, YFEW_SALDC;  B5R4I5, YFEW_SALEP;  
B5RCU8, YFEW_SALG2;  B4TD53, YFEW_SALHS;  B4T0K5, YFEW_SALNS;  
Q5PCQ2, YFEW_SALPA;  A9N307, YFEW_SALPB;  C0PZ64, YFEW_SALPC;  
B5BB26, YFEW_SALPK;  B4TR50, YFEW_SALSV;  Q8Z4S7, YFEW_SALTI;  
Q8ZN80, YFEW_SALTY;  

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