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ENZYME

ENZYME entry: EC 3.4.16.4

PURL: https://purl.expasy.org/enzyme/EC/3.4.16.4
Accepted Name
serine-type D-Ala-D-Ala carboxypeptidase
Alternative Name(s)
D-alanyl-D-alanine carboxypeptidase
DD-peptidase
DD-transpeptidase
Reaction catalysed
Preferential cleavage: (Ac)2-L-Lys-D-Ala-|-D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine
Comment(s)
  • A group of bacterial enzymes, membrane-bound.
  • Inhibited by beta-lactam antibiotics, which acylate the active site serine in the enzyme.
  • Distinct from EC 3.4.17.14.
  • Belongs to peptidase families S11, S12 and S13.
Cross-references
BRENDA3.4.16.4
EC2PDB3.4.16.4
ExplorEnz3.4.16.4
KEGG Ligand Database for Enzyme Nomenclature3.4.16.4
IUBMB Enzyme Nomenclature3.4.16.4
MEDLINEFind literature relating to 3.4.16.4
MetaCyc3.4.16.4
Rhea expert-curated reactions3.4.16.4
UniProtKB/Swiss-Prot
P08750, DACA_BACSUP0AEB4, DACA_ECO57P0AEB3, DACA_ECOL6
P0AEB2, DACA_ECOLIQ05523, DACA_GEOSEP44466, DACA_HAEIN
P35150, DACB_BACSUP24228, DACB_ECOLIP45161, DACB_HAEIN
P39844, DACC_BACSUP08506, DACC_ECOLIP33013, DACD_ECOLI
P37604, DACD_SALTYP38422, DACF_BACSUP39042, DACX_STRSK
P39045, DAC_ACTSPP15555, DAC_STRSRQ9I1K1, FTSI2_PSEAE
A2CI41, FTSIH_CHLATQ9MUV9, FTSIH_MESVIQ9TL36, FTSIH_NEPOL
P57317, FTSI_BUCAIO85297, FTSI_BUCAPQ89AQ0, FTSI_BUCBP
B8H0A0, FTSI_CAUVNP0AD69, FTSI_ECO57P0AD68, FTSI_ECOLI
P45059, FTSI_HAEING3XD46, FTSI_PSEAED0C8Z9, MRDA_ACIB2
P0AD67, MRDA_ECO57P0AD66, MRDA_ECOL6P0AD65, MRDA_ECOLI
P44469, MRDA_HAEINE1WGF1, MRDA_SALTSP0CL14, MRDA_SALTY
P54488, PBP2A_BACSUA0A0H2ZMF9, PBP2A_STRP2Q8DNB6, PBP2A_STRR6
Q07868, PBP2B_BACSUP16873, PBP2_NEIFLP08149, PBP2_NEIGO
P0A0U8, PBP2_NEIMAP0A0U9, PBP2_NEIMBA0R7G2, PBPA1_MYCS2
P71707, PBPA1_MYCTUA0R5I3, PBPA2_MYCS2I6YGX2, PBPA2_MYCTU
A0R0H1, PBPA3_MYCS2O66874, PBPA_AQUAEP39793, PBPA_BACSU
Q97GR5, PBPA_CLOABA7FY32, PBPA_CLOB1A5I6G4, PBPA_CLOBH
A7GHV1, PBPA_CLOBLA0PZT1, PBPA_CLONNQ0TNZ8, PBPA_CLOP1
Q8XJ01, PBPA_CLOPEQ0SRL7, PBPA_CLOPSQ891X1, PBPA_CLOTE
P02918, PBPA_ECOLIP31776, PBPA_HAEINA0QNG3, PBPA_MYCS2
P9WKD0, PBPA_MYCTOP9WKD1, PBPA_MYCTUO86088, PBPA_NEICI
O87626, PBPA_NEIFLQ5FAC7, PBPA_NEIG1O05131, PBPA_NEIGO
O87579, PBPA_NEILAP0A0Z5, PBPA_NEIMAP0A0Z6, PBPA_NEIMB
Q07806, PBPA_PSEAEQ1RKC5, PBPA_RICBRQ92G78, PBPA_RICCN
Q4UK08, PBPA_RICFEQ9ZCE9, PBPA_RICPRQ68VU2, PBPA_RICTY
Q00573, PBPA_STRORQ04707, PBPA_STRPNQ8DR59, PBPA_STRR6
Q9KNU5, PBPA_VIBCHQ9PGD4, PBPA_XYLFAQ87AW7, PBPA_XYLFT
P57296, PBPB_BUCAIQ89AR2, PBPB_BUCBPP02919, PBPB_ECOLI
P45345, PBPB_HAEINQ9KUC0, PBPB_VIBCHP42971, PBPC_BACSU
P40750, PBPD_BACSUP38050, PBPF_BACSUP70997, PBPG_BACSU
Q796K8, PBPH_BACSUO32032, PBPI_BACSUB1MDC3, PBP_MYCA9
Q86I79, PSCA_DICDIQ03524, SP5D_BACSUQ8XBJ0, YFEW_ECO57
P77619, YFEW_ECOLIB5F0K5, YFEW_SALA4Q57LN2, YFEW_SALCH
B5FQG8, YFEW_SALDCB5R4I5, YFEW_SALEPB5RCU8, YFEW_SALG2
B4TD53, YFEW_SALHSB4T0K5, YFEW_SALNSQ5PCQ2, YFEW_SALPA
A9N307, YFEW_SALPBC0PZ64, YFEW_SALPCB5BB26, YFEW_SALPK
B4TR50, YFEW_SALSVQ8Z4S7, YFEW_SALTIQ8ZN80, YFEW_SALTY

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.16.-
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