ENZYME entry: EC 3.4.17.11
Accepted Name |
Glutamate carboxypeptidase.
|
Alternative Name(s) |
Carboxypeptidase G. |
Carboxypeptidase G1. |
Carboxypeptidase G2. |
Reaction catalysed |
Release of C-terminal glutamate residues from a wide range of N-acylating moieties, including peptidyl, aminoacyl, benzoyl, benzyloxycarbonyl, folyl and pteroyl groups |
Cofactor(s) |
Zn(2+).
|
Comment(s) |
- Produced by pseudomonads, Flavobacterium sp. and Acinetobacter sp.
- Its ability to hydrolyze pteroyl-L-glutamate (folic acid) has led to
its use as a folate-depleting, antitumor agent.
- Belongs to peptidase family M20A.
|
Cross-references |
PROSITE | PDOC00613 |
BRENDA | 3.4.17.11 |
EC2PDB | 3.4.17.11 |
ExplorEnz | 3.4.17.11 |
PRIAM enzyme-specific profiles | 3.4.17.11 |
KEGG Ligand Database for Enzyme Nomenclature | 3.4.17.11 |
IUBMB Enzyme Nomenclature | 3.4.17.11 |
IntEnz | 3.4.17.11 |
MEDLINE | Find literature relating to 3.4.17.11 |
MetaCyc | 3.4.17.11 |
Rhea expert-curated reactions | 3.4.17.11 |
UniProtKB/Swiss-Prot |
|
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ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 3.4.17.-
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