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ENZYME entry: EC 3.4.17.23

Accepted Name
Angiotensin-converting enzyme 2.
Alternative Name(s)
ACE2.
Angiotensin converting enzyme 2.
Angiotensin converting enzyme-2.
Reaction catalysed
Angiotensin II + H(2)O <=> angiotensin-(1-7) + L-phenylalanine
Comment(s)
  • A transmembrane glycoprotein with an extracellular catalytic domain.
  • Angiotensin-converting enzyme 2 functions as a carboxypeptidase, cleaving a single C-terminal residue from a distinct range of substrates.
  • Catalytic efficiency is 400-fold higher with angiotensin II (1-8) as a substrate than with angiotensin I (1-10).
  • Angiotensin-converting enzyme 2 also efficiently hydrolyzes des- Arg(9)-bradykinin, but it does not hydrolyze bradykinin.
  • Belongs to peptidase family M2.
Cross-references
PROSITEPDOC00129
BRENDA3.4.17.23
EC2PDB3.4.17.23
ExplorEnz3.4.17.23
PRIAM enzyme-specific profiles3.4.17.23
KEGG Ligand Database for Enzyme Nomenclature3.4.17.23
IUBMB Enzyme Nomenclature3.4.17.23
IntEnz3.4.17.23
MEDLINEFind literature relating to 3.4.17.23
MetaCyc3.4.17.23
Rhea expert-curated reactions3.4.17.23
UniProtKB/Swiss-Prot
Q58DD0, ACE2_BOVIN;  Q56H28, ACE2_FELCA;  Q9BYF1, ACE2_HUMAN;  
Q8R0I0, ACE2_MOUSE;  Q56NL1, ACE2_PAGLA;  Q5RFN1, ACE2_PONAB;  
Q5EGZ1, ACE2_RAT;  

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