ID   3.4.17.24
DE   tubulin-glutamate carboxypeptidase.
AN   CCP5.
AN   cytosolic carboxypeptidase 5.
CA   (1) C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + H2O =
CA   C-terminal L-alpha-aminoacyl-L-glutamyl-[tubulin] + L-glutamate.
CA   (2) C-terminal L-alpha-aminoacyl-L-glutamyl-[tubulin] + H2O = C-terminal
CA   L-alpha-aminoacyl-[tubulin] + L-glutamate.
CC   -!- This is a subfamily of enzymes that cleave C-terminal and/or side
CC       chain amino acids from tubulins.
CC   -!- The dual-specificity enzymes can cleave both alpha- and gamma-linked
CC       L-glutamate from tubulins, removing the post-translationally added
CC       polyglutamyl side chains from the C-terminal regions.
CC   -!- In addition, the enzyme removes two glutamate residues from the
CC       C-terminus of beta-tubulin and detyrosinated alpha-tubulin (from
CC       which the C-terminal L-tyrosine has been removed by EC 3.4.17.17).
CC   -!- The latter is cleaved to Delta2-tubulin and further to Delta3-
CC       tubulin.
DR   E1C3P4, CBPC1_CHICK;  Q4U2V3, CBPC1_DANRE;  Q9UPW5, CBPC1_HUMAN;
DR   Q641K1, CBPC1_MOUSE;  Q6DD21, CBPC1_XENLA;  A9JRL3, CBPC1_XENTR;
DR   Q96MI9, CBPC4_HUMAN;  Q09M05, CBPC4_MOUSE;  D2GXM8, CBPC5_AILME;
DR   Q58CX9, CBPC5_BOVIN;  Q68EI3, CBPC5_DANRE;  Q8NDL9, CBPC5_HUMAN;
DR   Q09M02, CBPC5_MOUSE;  B2GV17, CBPC5_RAT  ;  B0JZV4, CBPC5_XENTR;
DR   Q5VU57, CBPC6_HUMAN;  Q09LZ8, CBPC6_MOUSE;
//