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ENZYME

ENZYME entry: EC 3.4.17.8

PURL: https://purl.expasy.org/enzyme/EC/3.4.17.8
Accepted Name
muramoylpentapeptide carboxypeptidase
Alternative Name(s)
carboxypeptidase D-alanyl-D-alanine
D-alanine carboxypeptidase
D-alanine-D-alanine-carboxypeptidase
D-alanyl-D-alanine carboxypeptidase
D-alanyl-D-alanine peptidase
DD-carboxypeptidase
DD-peptidase
PBP5
penicillin binding protein 5
UDP-N-acetylmuramoyl-tetrapeptidyl-D-alanine alanine-hydrolase
Reaction catalysed
UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + H2O = UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioyl-D-alanine + D-alanine
Comment(s)
  • Does not cleave the C-terminal D-alanine from the product of the above reaction, UDP-N-acetyl-muramoyl-L-alanyl-gamma-D-glutamyl-6- carboxy-L-lysyl-D-alanine.
  • Competitively inhibited by penicillins and cephalosporins.
  • Belongs to peptidase family M15.
  • Formerly EC 3.4.12.6.
Cross-references
BRENDA3.4.17.8
EC2PDB3.4.17.8
ExplorEnz3.4.17.8
KEGG Ligand Database for Enzyme Nomenclature3.4.17.8
IUBMB Enzyme Nomenclature3.4.17.8
MEDLINEFind literature relating to 3.4.17.8
MetaCyc3.4.17.8
Rhea expert-curated reactions3.4.17.8

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.17.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-