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ENZYME

ENZYME entry: EC 3.4.19.1

PURL: https://purl.expasy.org/enzyme/EC/3.4.19.1
Accepted Name
acylaminoacyl-peptidase
Alternative Name(s)
acylamino-acid-releasing enzyme
alpha-N-acylpeptide hydrolase
N-acylpeptide hydrolase
oxidized protein hydrolase
Reaction catalysed
  • Cleavage of an N-acetyl or N-formyl amino acid from the N-terminus of a polypeptide
  • Internal cleavage of oxidized and glycated proteins
Comment(s)
  • This is a bifunctional serine protease that has exopeptidase activity against N(alpha)-acylated peptides and endopeptidase activity against oxidized and glycated proteins.
  • In its exopeptidase mode the enzyme cleaves an N-acetyl or N-formyl amino acid from the N-terminus of a polypeptide.
  • This class of enzymes is evolutionary deeply conserved and is found in bacteria, archaea, animals and plants with different quartenary structures.
  • In humans, malfunction is linked to different types of cancer and sarcoma cell viability.
  • Belongs to peptidase family S9C.
  • Formerly EC 3.4.14.3.
Cross-references
BRENDA3.4.19.1
EC2PDB3.4.19.1
ExplorEnz3.4.19.1
KEGG Ligand Database for Enzyme Nomenclature3.4.19.1
IUBMB Enzyme Nomenclature3.4.19.1
MEDLINEFind literature relating to 3.4.19.1
MetaCyc3.4.19.1
Rhea expert-curated reactions3.4.19.1
UniProtKB/Swiss-Prot
Q0IXP9, AARE1_ORYSJQ338C0, AARE2_ORYSJQ84LM4, AARE_ARATH
P80227, ACPH_BOVINP13798, ACPH_HUMANQ8R146, ACPH_MOUSE
P19205, ACPH_PIGP25154, ACPH_RABITP13676, ACPH_RAT
Q9YBQ2, APEH_AERPE

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