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ENZYME entry: EC 3.4.19.16

Accepted Name
Glucosinolate gamma-glutamyl hydrolase.
Reaction catalysed
  • An S-((1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl)-L-glutathione + H(2)O <=> an S-((1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl)-L-cysteinylglycine + L-glutamate
  • (E)-1-(glutathion-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H(2)O <=> (E)-1-(glycylcystein-S-yl)-2-(1H-indol-3-yl)acetohydroximate + L-glutamate
  • 2-(glutathion-S-yl)-2-(1H-indol-3-yl)acetonitrile + H(2)O <=> 2-(glycylcystein-S-yl)-2-(1H-indol-3-yl)acetonitrile + L-glutamate
  • (Z)-1-(glutathion-S-yl)-2-phenylacetohydroximate + H(2)O <=> (Z)-1-(glycylcystein-S-yl)-2-phenylacetohydroximate + L-glutamate
Comment(s)
  • This enzyme, characterized from the plant Arabidopsis thaliana, participates in the biosynthesis of the plant defense compounds glucosinolates and camalexin.
  • It is the only known plant enzyme capable of hydrolyzing the gamma- glutamyl residue of glutathione in the cytosol.
Cross-references
BRENDA3.4.19.16
EC2PDB3.4.19.16
ExplorEnz3.4.19.16
PRIAM enzyme-specific profiles3.4.19.16
KEGG Ligand Database for Enzyme Nomenclature3.4.19.16
IUBMB Enzyme Nomenclature3.4.19.16
IntEnz3.4.19.16
MEDLINEFind literature relating to 3.4.19.16
MetaCyc3.4.19.16
UniProtKB/Swiss-Prot
Q9M0A7, GGP1_ARATH;  Q9M0A6, GGP2_ARATH;  Q9M0A5, GGP3_ARATH;  

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