Expasy logo

ENZYME

ENZYME entry: EC 3.4.19.3

PURL: https://purl.expasy.org/enzyme/EC/3.4.19.3
Accepted Name
pyroglutamyl-peptidase I
Alternative Name(s)
5-oxoprolyl-peptidase
PYRase
pyroglutamyl aminopeptidase
pyrrolidone-carboxylate peptidase
pyrrolidone carboxyl peptidase
Reaction catalysed
Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro
Comment(s)
  • Removes 5-oxoproline from various penultimate amino acid residues except L-proline.
  • Inhibited by thiol-blocking reagents.
  • Belongs to peptidase family C15.
  • Formerly EC 3.4.11.8.
Cross-references
Rhea expert-curated reactions3.4.19.3
ExplorEnz3.4.19.3
IUBMB Enzyme Nomenclature3.4.19.3
UniProtKB/Swiss-Prot
Q8RBX8, PCP1_CALS4Q7MAZ1, PCP1_PHOLLQ8XXE9, PCP1_RALN1
P58201, PCP1_SACS2P65678, PCP1_STRPNP65679, PCP1_STRR6
Q8R9J6, PCP2_CALS4Q7MZ76, PCP2_PHOLLQ8XT56, PCP2_RALN1
P58202, PCP2_SACS2Q97NG9, PCP2_STRPNQ5E531, PCP_ALIF1
B5FEA5, PCP_ALIFMA8MJA9, PCP_ALKOOC3P0R7, PCP_BACAA
C3LDV2, PCP_BACACA0RFP3, PCP_BACAHP46107, PCP_BACAM
Q81NT5, PCP_BACANB7JDC3, PCP_BACC0Q735N6, PCP_BACC1
B7IMH6, PCP_BACC2C1F026, PCP_BACC3B7H8H3, PCP_BACC4
B7HVU3, PCP_BACC7A7GQB6, PCP_BACCNB9J587, PCP_BACCQ
Q81BT3, PCP_BACCRQ639M5, PCP_BACCZQ6HH08, PCP_BACHK
Q65FR5, PCP_BACLDA9VKA7, PCP_BACMKP28618, PCP_BACSU
A7Z119, PCP_BACVZC0QXM0, PCP_BRAHWC0ZCX0, PCP_BREBN
Q7NT84, PCP_CHRVOA8AJA6, PCP_CITK8A5CM68, PCP_CLAM3
B2UZU4, PCP_CLOBAB2TK93, PCP_CLOBBQ186N3, PCP_CLOD6
Q0TQH4, PCP_CLOP1Q8XKH1, PCP_CLOPEQ0ST25, PCP_CLOPS
B5Y5X6, PCP_COPPDQ0KFE0, PCP_CUPNHQ477F9, PCP_CUPPJ
B2AG45, PCP_CUPTRQ9RX25, PCP_DEIRAA4W870, PCP_ENT38
Q838N8, PCP_ENTFAB2VBP1, PCP_ERWT9B7LKQ5, PCP_ESCF3
B0S415, PCP_FINM2Q8RI83, PCP_FUSNNQ7NHX6, PCP_GLOVI
Q9K6U4, PCP_HALH5B5XZE0, PCP_KLEV3Q5FMJ2, PCP_LACAC
B3W7M8, PCP_LACCBQ040L6, PCP_LACGAA8YX24, PCP_LACH4
Q74HE9, PCP_LACJOO87765, PCP_LACLMQ03CK3, PCP_LACP3
Q03P20, PCP_LEVBAB1HUY7, PCP_LYSSCP0A5R5, PCP_MYCBO
A1KFE2, PCP_MYCBPC1AJZ7, PCP_MYCBTB2HP18, PCP_MYCMM
A5TZ46, PCP_MYCTAP9WIJ4, PCP_MYCTOP9WIJ5, PCP_MYCTU
Q8ENE4, PCP_OCEIHQ6D7H1, PCP_PECASC6DCC7, PCP_PECCP
P42673, PCP_PSEFLC3JZR3, PCP_PSEFSQ9UYQ9, PCP_PYRAB
O73944, PCP_PYRFUO58321, PCP_PYRHOC3NL04, PCP_SACI1
C3MP49, PCP_SACI2C3N2L8, PCP_SACI3C4KEG7, PCP_SACI6
C3NAL6, PCP_SACI7A7X782, PCP_STAA1A6U575, PCP_STAA2
Q2FDH1, PCP_STAA3Q2FUS6, PCP_STAA8A5IWB7, PCP_STAA9
Q2YZA2, PCP_STAABQ5HCK7, PCP_STAACA6QKH8, PCP_STAAE
P65676, PCP_STAAMP65677, PCP_STAANQ6GDB4, PCP_STAAR
Q6G5Y4, PCP_STAASA8Z5J1, PCP_STAATQ53596, PCP_STAAU
Q8NUH2, PCP_STAAWB9DND6, PCP_STACTQ4L9S3, PCP_STAHJ
Q4A002, PCP_STAS1Q9RL48, PCP_STRCOP68896, PCP_STRP1
Q04L55, PCP_STRP2P0DC94, PCP_STRP3Q5XDD4, PCP_STRP6
C1C6J3, PCP_STRP7Q8P243, PCP_STRP8Q1JD20, PCP_STRPB
Q1JMZ5, PCP_STRPCQ1JI40, PCP_STRPDQ1J7Y1, PCP_STRPF
A2RFZ5, PCP_STRPGB1IB28, PCP_STRPIQ48UT7, PCP_STRPM
P0DC95, PCP_STRPQB5XK96, PCP_STRPZA4W0R4, PCP_STRS2
A4VUH1, PCP_STRSYB7IEE2, PCP_THEABQ5JEL5, PCP_THEKO
O07883, PCP_THELNA6LL24, PCP_THEM4B6YUJ5, PCP_THEON
B0K8Z7, PCP_THEP3B0K0D9, PCP_THEPXQ73RB6, PCP_TREDE
A7N3R7, PCP_VIBC1Q87IL9, PCP_VIBPAQ8D4N5, PCP_VIBVU
Q7MG84, PCP_VIBVYA1JR34, PCP_YERE8A7FFS3, PCP_YERP3
Q1C571, PCP_YERPAB2KA64, PCP_YERPBQ8ZD86, PCP_YERPE
A9R3Y5, PCP_YERPGQ1CKF9, PCP_YERPNA4TKZ3, PCP_YERPP
Q667T6, PCP_YERPSB1JRB0, PCP_YERPYQ9NXJ5, PGPI_HUMAN
Q9ESW8, PGPI_MOUSEQ76IC5, PGPI_RAT
BRENDA3.4.19.3
MetaCyc3.4.19.3
KEGG Ligand Database for Enzyme Nomenclature3.4.19.3
EC2PDB3.4.19.3
MEDLINEFind literature relating to 3.4.19.3

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.19.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-