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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 3.4.19.3

Accepted Name
Pyroglutamyl-peptidase I.
Alternative Name(s)
5-oxoprolyl-peptidase.
PYRase.
Pyroglutamyl aminopeptidase.
Pyrrolidone carboxyl peptidase.
Pyrrolidone-carboxylate peptidase.
Reaction catalysed
Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro
Comment(s)
  • Removes 5-oxoproline from various penultimate amino acid residues except L-proline.
  • Inhibited by thiol-blocking reagents.
  • Belongs to peptidase family C15.
  • Formerly EC 3.4.11.8.
Cross-references
PROSITEPDOC01036
BRENDA3.4.19.3
EC2PDB3.4.19.3
ExplorEnz3.4.19.3
PRIAM enzyme-specific profiles3.4.19.3
KEGG Ligand Database for Enzyme Nomenclature3.4.19.3
IUBMB Enzyme Nomenclature3.4.19.3
IntEnz3.4.19.3
MEDLINEFind literature relating to 3.4.19.3
MetaCyc3.4.19.3
UniProtKB/Swiss-Prot
Q8RBX8, PCP1_CALS4;  Q7MAZ1, PCP1_PHOLL;  Q8XXE9, PCP1_RALSO;  
P65678, PCP1_STRPN;  P65679, PCP1_STRR6;  P58201, PCP1_SULSO;  
Q8R9J6, PCP2_CALS4;  Q7MZ76, PCP2_PHOLL;  Q8XT56, PCP2_RALSO;  
Q97NG9, PCP2_STRPN;  P58202, PCP2_SULSO;  Q5E531, PCP_ALIF1;  
B5FEA5, PCP_ALIFM;  A8MJA9, PCP_ALKOO;  C3P0R7, PCP_BACAA;  
C3LDV2, PCP_BACAC;  A0RFP3, PCP_BACAH;  P46107, PCP_BACAM;  
Q81NT5, PCP_BACAN;  B7JDC3, PCP_BACC0;  Q735N6, PCP_BACC1;  
B7IMH6, PCP_BACC2;  C1F026, PCP_BACC3;  B7H8H3, PCP_BACC4;  
B7HVU3, PCP_BACC7;  A7GQB6, PCP_BACCN;  B9J587, PCP_BACCQ;  
Q81BT3, PCP_BACCR;  Q639M5, PCP_BACCZ;  Q9K6U4, PCP_BACHD;  
Q6HH08, PCP_BACHK;  Q65FR5, PCP_BACLD;  P28618, PCP_BACSU;  
A7Z119, PCP_BACVZ;  A9VKA7, PCP_BACWK;  C0QXM0, PCP_BRAHW;  
C0ZCX0, PCP_BREBN;  Q7NT84, PCP_CHRVO;  A8AJA6, PCP_CITK8;  
A5CM68, PCP_CLAM3;  B2UZU4, PCP_CLOBA;  B2TK93, PCP_CLOBB;  
Q0TQH4, PCP_CLOP1;  Q8XKH1, PCP_CLOPE;  Q0ST25, PCP_CLOPS;  
B5Y5X6, PCP_COPPD;  Q0KFE0, PCP_CUPNH;  Q477F9, PCP_CUPNJ;  
B2AG45, PCP_CUPTR;  Q9RX25, PCP_DEIRA;  A4W870, PCP_ENT38;  
Q838N8, PCP_ENTFA;  B2VBP1, PCP_ERWT9;  B7LKQ5, PCP_ESCF3;  
B0S415, PCP_FINM2;  Q8RI83, PCP_FUSNN;  Q7NHX6, PCP_GLOVI;  
B5XZE0, PCP_KLEP3;  Q5FMJ2, PCP_LACAC;  Q03P20, PCP_LACBA;  
B3W7M8, PCP_LACCB;  Q040L6, PCP_LACGA;  A8YX24, PCP_LACH4;  
Q74HE9, PCP_LACJO;  O87765, PCP_LACLM;  Q03CK3, PCP_LACP3;  
B1HUY7, PCP_LYSSC;  P0A5R5, PCP_MYCBO;  A1KFE2, PCP_MYCBP;  
C1AJZ7, PCP_MYCBT;  B2HP18, PCP_MYCMM;  A5TZ46, PCP_MYCTA;  
P9WIJ4, PCP_MYCTO;  P9WIJ5, PCP_MYCTU;  Q8ENE4, PCP_OCEIH;  
Q6D7H1, PCP_PECAS;  C6DCC7, PCP_PECCP;  Q186N3, PCP_PEPD6;  
P42673, PCP_PSEFL;  C3JZR3, PCP_PSEFS;  Q9UYQ9, PCP_PYRAB;  
O73944, PCP_PYRFU;  O58321, PCP_PYRHO;  A7X782, PCP_STAA1;  
A6U575, PCP_STAA2;  Q2FDH1, PCP_STAA3;  Q2FUS6, PCP_STAA8;  
A5IWB7, PCP_STAA9;  Q2YZA2, PCP_STAAB;  Q5HCK7, PCP_STAAC;  
A6QKH8, PCP_STAAE;  P65676, PCP_STAAM;  P65677, PCP_STAAN;  
Q6GDB4, PCP_STAAR;  Q6G5Y4, PCP_STAAS;  A8Z5J1, PCP_STAAT;  
Q53596, PCP_STAAU;  Q8NUH2, PCP_STAAW;  B9DND6, PCP_STACT;  
Q4L9S3, PCP_STAHJ;  Q4A002, PCP_STAS1;  Q9RL48, PCP_STRCO;  
P68896, PCP_STRP1;  Q04L55, PCP_STRP2;  P0DC94, PCP_STRP3;  
Q5XDD4, PCP_STRP6;  C1C6J3, PCP_STRP7;  Q8P243, PCP_STRP8;  
Q1JD20, PCP_STRPB;  Q1JMZ5, PCP_STRPC;  Q1JI40, PCP_STRPD;  
Q1J7Y1, PCP_STRPF;  A2RFZ5, PCP_STRPG;  B1IB28, PCP_STRPI;  
Q48UT7, PCP_STRPM;  P0DC95, PCP_STRPQ;  B5XK96, PCP_STRPZ;  
A4W0R4, PCP_STRS2;  A4VUH1, PCP_STRSY;  C3N2L8, PCP_SULIA;  
C4KEG7, PCP_SULIK;  C3MP49, PCP_SULIL;  C3NL04, PCP_SULIN;  
C3NAL6, PCP_SULIY;  B7IEE2, PCP_THEAB;  Q5JEL5, PCP_THEKO;  
O07883, PCP_THELN;  A6LL24, PCP_THEM4;  B6YUJ5, PCP_THEON;  
B0K8Z7, PCP_THEP3;  B0K0D9, PCP_THEPX;  Q73RB6, PCP_TREDE;  
A7N3R7, PCP_VIBCB;  Q87IL9, PCP_VIBPA;  Q8D4N5, PCP_VIBVU;  
Q7MG84, PCP_VIBVY;  A1JR34, PCP_YERE8;  A7FFS3, PCP_YERP3;  
Q1C571, PCP_YERPA;  B2KA64, PCP_YERPB;  Q8ZD86, PCP_YERPE;  
A9R3Y5, PCP_YERPG;  Q1CKF9, PCP_YERPN;  A4TKZ3, PCP_YERPP;  
Q667T6, PCP_YERPS;  B1JRB0, PCP_YERPY;  Q9NXJ5, PGPI_HUMAN;  
Q9ESW8, PGPI_MOUSE;  Q76IC5, PGPI_RAT;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.19.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-