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ENZYME

ENZYME entry: EC 3.4.19.3

PURL: https://purl.expasy.org/enzyme/EC/3.4.19.3
Accepted Name
pyroglutamyl-peptidase I
Alternative Name(s)
5-oxoprolyl-peptidase
PYRase
pyroglutamyl aminopeptidase
pyrrolidone-carboxylate peptidase
pyrrolidone carboxyl peptidase
Reaction catalysed
Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro
Comment(s)
  • Removes 5-oxoproline from various penultimate amino acid residues except L-proline.
  • Inhibited by thiol-blocking reagents.
  • Belongs to peptidase family C15.
  • Formerly EC 3.4.11.8.
Cross-references
BRENDA3.4.19.3
EC2PDB3.4.19.3
ExplorEnz3.4.19.3
KEGG Ligand Database for Enzyme Nomenclature3.4.19.3
IUBMB Enzyme Nomenclature3.4.19.3
MEDLINEFind literature relating to 3.4.19.3
MetaCyc3.4.19.3
Rhea expert-curated reactions3.4.19.3
UniProtKB/Swiss-Prot
Q8RBX8, PCP1_CALS4Q7MAZ1, PCP1_PHOLLQ8XXE9, PCP1_RALN1
P58201, PCP1_SACS2P65678, PCP1_STRPNP65679, PCP1_STRR6
Q8R9J6, PCP2_CALS4Q7MZ76, PCP2_PHOLLQ8XT56, PCP2_RALN1
P58202, PCP2_SACS2Q97NG9, PCP2_STRPNQ5E531, PCP_ALIF1
B5FEA5, PCP_ALIFMA8MJA9, PCP_ALKOOC3P0R7, PCP_BACAA
C3LDV2, PCP_BACACA0RFP3, PCP_BACAHP46107, PCP_BACAM
Q81NT5, PCP_BACANB7JDC3, PCP_BACC0Q735N6, PCP_BACC1
B7IMH6, PCP_BACC2C1F026, PCP_BACC3B7H8H3, PCP_BACC4
B7HVU3, PCP_BACC7A7GQB6, PCP_BACCNB9J587, PCP_BACCQ
Q81BT3, PCP_BACCRQ639M5, PCP_BACCZQ6HH08, PCP_BACHK
Q65FR5, PCP_BACLDA9VKA7, PCP_BACMKP28618, PCP_BACSU
A7Z119, PCP_BACVZC0QXM0, PCP_BRAHWC0ZCX0, PCP_BREBN
Q7NT84, PCP_CHRVOA8AJA6, PCP_CITK8A5CM68, PCP_CLAM3
B2UZU4, PCP_CLOBAB2TK93, PCP_CLOBBQ186N3, PCP_CLOD6
Q0TQH4, PCP_CLOP1Q8XKH1, PCP_CLOPEQ0ST25, PCP_CLOPS
B5Y5X6, PCP_COPPDQ0KFE0, PCP_CUPNHQ477F9, PCP_CUPPJ
B2AG45, PCP_CUPTRQ9RX25, PCP_DEIRAA4W870, PCP_ENT38
Q838N8, PCP_ENTFAB2VBP1, PCP_ERWT9B7LKQ5, PCP_ESCF3
B0S415, PCP_FINM2Q8RI83, PCP_FUSNNQ7NHX6, PCP_GLOVI
Q9K6U4, PCP_HALH5B5XZE0, PCP_KLEP3Q5FMJ2, PCP_LACAC
B3W7M8, PCP_LACCBQ040L6, PCP_LACGAA8YX24, PCP_LACH4
Q74HE9, PCP_LACJOO87765, PCP_LACLMQ03CK3, PCP_LACP3
Q03P20, PCP_LEVBAB1HUY7, PCP_LYSSCP0A5R5, PCP_MYCBO
A1KFE2, PCP_MYCBPC1AJZ7, PCP_MYCBTB2HP18, PCP_MYCMM
A5TZ46, PCP_MYCTAP9WIJ4, PCP_MYCTOP9WIJ5, PCP_MYCTU
Q8ENE4, PCP_OCEIHQ6D7H1, PCP_PECASC6DCC7, PCP_PECCP
P42673, PCP_PSEFLC3JZR3, PCP_PSEFSQ9UYQ9, PCP_PYRAB
O73944, PCP_PYRFUO58321, PCP_PYRHOC3NL04, PCP_SACI1
C3MP49, PCP_SACI2C3N2L8, PCP_SACI3C4KEG7, PCP_SACI6
C3NAL6, PCP_SACI7A7X782, PCP_STAA1A6U575, PCP_STAA2
Q2FDH1, PCP_STAA3Q2FUS6, PCP_STAA8A5IWB7, PCP_STAA9
Q2YZA2, PCP_STAABQ5HCK7, PCP_STAACA6QKH8, PCP_STAAE
P65676, PCP_STAAMP65677, PCP_STAANQ6GDB4, PCP_STAAR
Q6G5Y4, PCP_STAASA8Z5J1, PCP_STAATQ53596, PCP_STAAU
Q8NUH2, PCP_STAAWB9DND6, PCP_STACTQ4L9S3, PCP_STAHJ
Q4A002, PCP_STAS1Q9RL48, PCP_STRCOP68896, PCP_STRP1
Q04L55, PCP_STRP2P0DC94, PCP_STRP3Q5XDD4, PCP_STRP6
C1C6J3, PCP_STRP7Q8P243, PCP_STRP8Q1JD20, PCP_STRPB
Q1JMZ5, PCP_STRPCQ1JI40, PCP_STRPDQ1J7Y1, PCP_STRPF
A2RFZ5, PCP_STRPGB1IB28, PCP_STRPIQ48UT7, PCP_STRPM
P0DC95, PCP_STRPQB5XK96, PCP_STRPZA4W0R4, PCP_STRS2
A4VUH1, PCP_STRSYB7IEE2, PCP_THEABQ5JEL5, PCP_THEKO
O07883, PCP_THELNA6LL24, PCP_THEM4B6YUJ5, PCP_THEON
B0K8Z7, PCP_THEP3B0K0D9, PCP_THEPXQ73RB6, PCP_TREDE
A7N3R7, PCP_VIBC1Q87IL9, PCP_VIBPAQ8D4N5, PCP_VIBVU
Q7MG84, PCP_VIBVYA1JR34, PCP_YERE8A7FFS3, PCP_YERP3
Q1C571, PCP_YERPAB2KA64, PCP_YERPBQ8ZD86, PCP_YERPE
A9R3Y5, PCP_YERPGQ1CKF9, PCP_YERPNA4TKZ3, PCP_YERPP
Q667T6, PCP_YERPSB1JRB0, PCP_YERPYQ9NXJ5, PGPI_HUMAN
Q9ESW8, PGPI_MOUSEQ76IC5, PGPI_RAT

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.19.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-