ENZYME entry: EC 3.4.19.6
Accepted Name |
Pyroglutamyl-peptidase II.
|
Alternative Name(s) |
PAP-II. |
Pyroglutamyl aminopeptidase II. |
Thyroliberinase. |
Thyrotropin-releasing hormone degrading ectoenzyme. |
TRH-DE. |
TRH-degrading ectoenzyme. |
TRH-specific aminopeptidase. |
Reaction catalysed |
Release of the N-terminal pyroglutamyl group from pGlu-|-His-Xaa tripeptides and pGlu-|-His-Xaa-Gly tetrapeptides |
Cofactor(s) |
Zn(2+).
|
Comment(s) |
- Highly specific for thyrotropin releasing hormone (pyroglutamyl-
histidyl-prolylamide).
- Will not cleave the pyroglutamyl-histidyl bond of luteinizing hormone
releasing hormone.
- Found in serum and brain.
- Inhibited by metal chelators.
- Belongs to peptidase family M1.
|
Cross-references |
PROSITE | PDOC00129 |
BRENDA | 3.4.19.6 |
EC2PDB | 3.4.19.6 |
ExplorEnz | 3.4.19.6 |
PRIAM enzyme-specific profiles | 3.4.19.6 |
KEGG Ligand Database for Enzyme Nomenclature | 3.4.19.6 |
IUBMB Enzyme Nomenclature | 3.4.19.6 |
IntEnz | 3.4.19.6 |
MEDLINE | Find literature relating to 3.4.19.6 |
MetaCyc | 3.4.19.6 |
UniProtKB/Swiss-Prot |
|
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