ID 3.4.19.9 DE folate gamma-glutamyl hydrolase. AN carboxypeptidase G. AN conjugase. AN folate conjugase. AN gamma-glutamyl hydrolase. AN gamma-Glu-X carboxypeptidase. AN lysosomal gamma-glutamyl carboxypeptidase. AN pteroyl-poly-alpha-glutamate hydrolase. AN tetrahydropteroyl-poly-gamma-glutamyl gamma-glutamyl hydrolase. CA (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + (n-1) H2O = (6S)-5,6,7,8- CA tetrahydrofolate + (n-1) L-glutamate. CC -!- The enzyme, which occurs only in animals and plants, can be either CC endo- and/or exopeptidase. CC -!- It acts on tetrahydropteroyl polyglutamates and their modified forms, CC as well as the polyglutamates of the folate breakdown product CC N-(4-aminobenzoyl)-L-glutamate (pABA-Glu). CC -!- The initial cleavage may release either monoglutamate or poly-gamma- CC glutamate of two or more residues, depending on the specific enzyme. CC -!- For example, GGH1 from the plant Arabidopsis thaliana cleaves CC pentaglutamates, mainly to di- and triglutamates, whereas GGH2 from CC the same organism yields mainly monoglutamates. CC -!- The enzyme is lysosomal (and secreted) in animals and vacuolar in CC plants. CC -!- Belongs to peptidase family C26. CC -!- Formerly EC 3.4.12.10 and EC 3.4.22.12. DR Q9SYL6, GGH1_ARATH ; O65355, GGH2_ARATH ; Q9ZV85, GGH3_ARATH ; DR Q54LN4, GGHA_DICDI ; Q54HL4, GGHB_DICDI ; A7YWG4, GGH_BOVIN ; DR Q92820, GGH_HUMAN ; Q9Z0L8, GGH_MOUSE ; Q62867, GGH_RAT ; DR P93164, GGH_SOYBN ; //