ID 3.4.21.105 DE rhomboid protease. CA Cleaves type-1 transmembrane domains using a catalytic dyad composed of CA serine and histidine that are contributed by different transmembrane CA domains. CC -!- These endopeptidases are multi-spanning membrane proteins. CC -!- Their catalytic site is embedded within the membrane and they cleave CC type-1 transmembrane domains. CC -!- Important for embryo development in Drosophila melanogaster. CC -!- Rhomboid is a key regulator of EGF receptor signaling and is CC responsible for cleaving Spitz, the main ligand of the Drosophila EGF CC receptor pathway. CC -!- Parasite-encoded rhomboid enzymes are also important for invasion of CC host cells by Toxoplasma and the malaria parasite. CC -!- Belongs to peptidase family S54. DR P46116, AARA_PROST ; A8AQX4, GLPG_CITK8 ; A7ZSV4, GLPG_ECO24 ; DR B7UKC8, GLPG_ECO27 ; B7MDQ0, GLPG_ECO45 ; B7L4V0, GLPG_ECO55 ; DR Q8X6Z6, GLPG_ECO57 ; B5YTX6, GLPG_ECO5E ; B7NMI8, GLPG_ECO7I ; DR B7N156, GLPG_ECO81 ; B7M2I4, GLPG_ECO8A ; C4ZVX5, GLPG_ECOBW ; DR B1X769, GLPG_ECODH ; A8A5N2, GLPG_ECOHS ; A1AGU7, GLPG_ECOK1 ; DR Q0TC44, GLPG_ECOL5 ; Q8FCS5, GLPG_ECOL6 ; B1IP42, GLPG_ECOLC ; DR P09391, GLPG_ECOLI ; B7NE28, GLPG_ECOLU ; B6I2Y7, GLPG_ECOSE ; DR B1LI84, GLPG_ECOSM ; Q1R5L1, GLPG_ECOUT ; A4WFK8, GLPG_ENT38 ; DR B7LSC6, GLPG_ESCF3 ; P44783, GLPG_HAEIN ; B5XTR5, GLPG_KLEP3 ; DR A6TF43, GLPG_KLEP7 ; Q6CZL3, GLPG_PECAS ; Q7N9W4, GLPG_PHOLL ; DR B5F8P0, GLPG_SALA4 ; A9MMA7, GLPG_SALAR ; Q57IV1, GLPG_SALCH ; DR B5FKE3, GLPG_SALDC ; B5R383, GLPG_SALEP ; B5R7J1, GLPG_SALG2 ; DR B4TKV0, GLPG_SALHS ; B4SVM1, GLPG_SALNS ; Q5PLZ8, GLPG_SALPA ; DR B5BHH5, GLPG_SALPK ; B4TY77, GLPG_SALSV ; Q8Z229, GLPG_SALTI ; DR Q8ZLH5, GLPG_SALTY ; A8GKU2, GLPG_SERP5 ; B2U3N2, GLPG_SHIB3 ; DR Q31VK9, GLPG_SHIBS ; Q32AN6, GLPG_SHIDS ; Q0SZP2, GLPG_SHIF8 ; DR Q83PV6, GLPG_SHIFL ; Q3YWA4, GLPG_SHISS ; Q2NQH3, GLPG_SODGM ; DR A1JSF0, GLPG_YERE8 ; A7FNW6, GLPG_YERP3 ; Q1C2L2, GLPG_YERPA ; DR B2K5W4, GLPG_YERPB ; Q7CFX8, GLPG_YERPE ; Q1CCK6, GLPG_YERPN ; DR A4TGR2, GLPG_YERPP ; Q664J1, GLPG_YERPS ; B1JHY8, GLPG_YERPY ; DR P54493, GLUP_BACSU ; Q58EK4, PARLA_DANRE; Q2KHV4, PARL_BOVIN ; DR A1Z8R8, PARL_DROME ; Q9H300, PARL_HUMAN ; Q5XJY4, PARL_MOUSE ; DR Q5R5H4, PARL_PONAB ; Q3B8P0, PARL_RAT ; P53259, PCP1_YEAST ; DR Q5AH12, RBD2_CANAL ; Q6FSG0, RBD2_CANGA ; Q6BSA9, RBD2_DEBHA ; DR Q755H8, RBD2_EREGS ; Q4I4A4, RBD2_GIBZE ; Q6CR06, RBD2_KLULA ; DR Q7S4V5, RBD2_NEUCR ; Q874X5, RBD2_PODAS ; O74926, RBD2_SCHPO ; DR Q6CDV6, RBD2_YARLI ; Q12270, RBD2_YEAST ; B0Y8W1, RBDB_ASPFC ; DR Q4WLP9, RBDB_ASPFU ; Q0WQX7, RBL1_ARATH ; Q9CAN1, RBL2_ARATH ; DR Q9LYP1, RBL3_ARATH ; F4JBM4, RBL4_ARATH ; Q9SSR0, RBL5_ARATH ; DR Q8VZ48, RBL6_ARATH ; O82756, RBL7_ARATH ; O75783, RHBL1_HUMAN; DR Q8VC82, RHBL1_MOUSE; O88779, RHBL1_RAT ; Q695U0, RHBL1_TOXGO; DR Q9NX52, RHBL2_HUMAN; A2AGA4, RHBL2_MOUSE; Q695T9, RHBL2_TOXGO; DR P58872, RHBL3_HUMAN; P58873, RHBL3_MOUSE; Q6IUY1, RHBL3_TOXGO; DR Q8TEB9, RHBL4_HUMAN; Q8BHC7, RHBL4_MOUSE; Q5RBS4, RHBL4_PONAB; DR Q4V8F3, RHBL4_RAT ; Q695T8, RHBL4_TOXGO; Q6GV23, RHBL5_TOXGO; DR Q2PP52, RHBL6_TOXGO; Q19821, RHOM1_CAEEL; P20350, RHOM_DROME ; DR C8VCL5, Y0929_EMENI; //