ID   3.4.21.105
DE   rhomboid protease.
CA   Cleaves type-1 transmembrane domains using a catalytic dyad composed of
CA   serine and histidine that are contributed by different transmembrane
CA   domains.
CC   -!- These endopeptidases are multi-spanning membrane proteins.
CC   -!- Their catalytic site is embedded within the membrane and they cleave
CC       type-1 transmembrane domains.
CC   -!- Important for embryo development in Drosophila melanogaster.
CC   -!- Rhomboid is a key regulator of EGF receptor signaling and is
CC       responsible for cleaving Spitz, the main ligand of the Drosophila EGF
CC       receptor pathway.
CC   -!- Parasite-encoded rhomboid enzymes are also important for invasion of
CC       host cells by Toxoplasma and the malaria parasite.
CC   -!- Belongs to peptidase family S54.
DR   P46116, AARA_PROST ;  A8AQX4, GLPG_CITK8 ;  A7ZSV4, GLPG_ECO24 ;
DR   B7UKC8, GLPG_ECO27 ;  B7MDQ0, GLPG_ECO45 ;  B7L4V0, GLPG_ECO55 ;
DR   Q8X6Z6, GLPG_ECO57 ;  B5YTX6, GLPG_ECO5E ;  B7NMI8, GLPG_ECO7I ;
DR   B7N156, GLPG_ECO81 ;  B7M2I4, GLPG_ECO8A ;  C4ZVX5, GLPG_ECOBW ;
DR   B1X769, GLPG_ECODH ;  A8A5N2, GLPG_ECOHS ;  A1AGU7, GLPG_ECOK1 ;
DR   Q0TC44, GLPG_ECOL5 ;  Q8FCS5, GLPG_ECOL6 ;  B1IP42, GLPG_ECOLC ;
DR   P09391, GLPG_ECOLI ;  B7NE28, GLPG_ECOLU ;  B6I2Y7, GLPG_ECOSE ;
DR   B1LI84, GLPG_ECOSM ;  Q1R5L1, GLPG_ECOUT ;  A4WFK8, GLPG_ENT38 ;
DR   B7LSC6, GLPG_ESCF3 ;  P44783, GLPG_HAEIN ;  B5XTR5, GLPG_KLEP3 ;
DR   A6TF43, GLPG_KLEP7 ;  Q6CZL3, GLPG_PECAS ;  Q7N9W4, GLPG_PHOLL ;
DR   B5F8P0, GLPG_SALA4 ;  A9MMA7, GLPG_SALAR ;  Q57IV1, GLPG_SALCH ;
DR   B5FKE3, GLPG_SALDC ;  B5R383, GLPG_SALEP ;  B5R7J1, GLPG_SALG2 ;
DR   B4TKV0, GLPG_SALHS ;  B4SVM1, GLPG_SALNS ;  Q5PLZ8, GLPG_SALPA ;
DR   B5BHH5, GLPG_SALPK ;  B4TY77, GLPG_SALSV ;  Q8Z229, GLPG_SALTI ;
DR   Q8ZLH5, GLPG_SALTY ;  A8GKU2, GLPG_SERP5 ;  B2U3N2, GLPG_SHIB3 ;
DR   Q31VK9, GLPG_SHIBS ;  Q32AN6, GLPG_SHIDS ;  Q0SZP2, GLPG_SHIF8 ;
DR   Q83PV6, GLPG_SHIFL ;  Q3YWA4, GLPG_SHISS ;  Q2NQH3, GLPG_SODGM ;
DR   A1JSF0, GLPG_YERE8 ;  A7FNW6, GLPG_YERP3 ;  Q1C2L2, GLPG_YERPA ;
DR   B2K5W4, GLPG_YERPB ;  Q7CFX8, GLPG_YERPE ;  Q1CCK6, GLPG_YERPN ;
DR   A4TGR2, GLPG_YERPP ;  Q664J1, GLPG_YERPS ;  B1JHY8, GLPG_YERPY ;
DR   P54493, GLUP_BACSU ;  Q58EK4, PARLA_DANRE;  Q2KHV4, PARL_BOVIN ;
DR   A1Z8R8, PARL_DROME ;  Q9H300, PARL_HUMAN ;  Q5XJY4, PARL_MOUSE ;
DR   Q5R5H4, PARL_PONAB ;  Q3B8P0, PARL_RAT   ;  P53259, PCP1_YEAST ;
DR   Q4WLP9, RBD2_ASPFU ;  Q5AH12, RBD2_CANAL ;  Q6FSG0, RBD2_CANGA ;
DR   Q6BSA9, RBD2_DEBHA ;  Q755H8, RBD2_EREGS ;  Q4I4A4, RBD2_GIBZE ;
DR   Q6CR06, RBD2_KLULA ;  Q7S4V5, RBD2_NEUCR ;  Q874X5, RBD2_PODAS ;
DR   O74926, RBD2_SCHPO ;  Q6CDV6, RBD2_YARLI ;  Q12270, RBD2_YEAST ;
DR   Q0WQX7, RBL1_ARATH ;  Q9CAN1, RBL2_ARATH ;  Q9LYP1, RBL3_ARATH ;
DR   F4JBM4, RBL4_ARATH ;  Q9SSR0, RBL5_ARATH ;  Q8VZ48, RBL6_ARATH ;
DR   O82756, RBL7_ARATH ;  O75783, RHBL1_HUMAN;  Q8VC82, RHBL1_MOUSE;
DR   O88779, RHBL1_RAT  ;  Q695U0, RHBL1_TOXGO;  Q9NX52, RHBL2_HUMAN;
DR   A2AGA4, RHBL2_MOUSE;  Q695T9, RHBL2_TOXGO;  P58872, RHBL3_HUMAN;
DR   P58873, RHBL3_MOUSE;  Q6IUY1, RHBL3_TOXGO;  Q8TEB9, RHBL4_HUMAN;
DR   Q8BHC7, RHBL4_MOUSE;  Q5RBS4, RHBL4_PONAB;  Q4V8F3, RHBL4_RAT  ;
DR   Q695T8, RHBL4_TOXGO;  Q6GV23, RHBL5_TOXGO;  Q2PP52, RHBL6_TOXGO;
DR   Q19821, RHOM1_CAEEL;  P20350, RHOM_DROME ;  C8VCL5, Y0929_EMENI;
//