ID   3.4.21.109
DE   matriptase.
AN   epithin.
AN   membrane-type serine protease 1.
AN   MT-SP1.
AN   prostamin.
AN   serine endopeptidase SNC19.
AN   serine protease 14.
AN   serine protease TADG-15.
AN   tumor-associated differentially-expressed gene 15 protein.
CA   Cleaves various synthetic substrates with Arg or Lys at the P1 position
CA   and prefers small side-chain amino acids, such as Ala and Gly, at the P2
CA   position.
CC   -!- This trypsin-like integral-membrane serine peptidase has been
CC       implicated in breast cancer invasion and metastasis.
CC   -!- The enzyme can activate hepatocyte growth factor/scattering factor
CC       (HGF/SF) by cleavage of the two-chain forms at an Arg residue to give
CC       active alpha- and beta-HGF, but it does not activate plasminogen,
CC       which shares high similarity with HGF.
CC   -!- The enzyme can also activate urokinase plasminogen activator (uPA),
CC       which initiates the matrix-degrading peptidase cascade.
CC   -!- Hemojuvelin has been shown to be a physiologic substrate for
CC       matriptase-2.
CC   -!- Belongs to peptidase family S1A.
DR   Q0IIH7, ST14_BOVIN ;  Q9Y5Y6, ST14_HUMAN ;  P56677, ST14_MOUSE ;
//