ID   3.4.21.111
DE   aqualysin 1.
AN   caldolysin.
CA   Exhibits low specificity toward esters of amino acids with small
CA   hydrophobic or aromatic residues at the P1 position.
CC   -!- This enzyme from the extreme thermophile, Thermus aquaticus, is an
CC       alkaline serine peptidase.
CC   -!- It has three subsites, S1, S2, and S3, in the substrate binding site.
CC   -!- The preferred amino acids at the S1 site are Ala and Phe, at the S2
CC       site are Ala and norleucine and at the S3 site are Phe and Ile.
CC   -!- These specificities are similar to those of EC 3.4.21.62 and
CC       EC 3.4.21.64.
CC   -!- The enzyme displays broad specificity for cleavage of insulin B-chain
CC       and hydrolyzes elastin substrates such as succinyl-(Ala)n-p-
CC       nitroanilide (n = 1,2,3) and some peptide esters.
CC   -!- Belongs to peptidase family S8A.
DR   P08594, AQL1_THEAQ ;
//