ID 3.4.21.117 DE stratum corneum chymotryptic enzyme. AN kallikrein 7. AN SCCE. AN serine protease 6. CA Cleavage of proteins with aromatic side chains in the P1 position. CC -!- This enzyme has wide substrate specificity, being able to degrade CC heat-denatured bovine casein and the alpha-chain of native human CC fibrinogen. CC -!- It cleaves the B chain of bovine insulin at 6-Leu-|-Cya-7 (cysteic CC acid), 16-Tyr-|-Leu-17, 25-Phe-|-Tyr-26 and 26-Tyr-|-Thr-27. CC -!- It is thought to play a role in the desquamation (skin-shedding) of CC the outer layer of skin, the stratum corneum, by degrading CC intercellular cohesive structures. CC -!- Belongs to peptidase family S1A. DR P49862, KLK7_HUMAN ; Q91VE3, KLK7_MOUSE ; //