ID   3.4.21.122
DE   transmembrane protease serine 2.
AN   epitheliasin.
CA   The enzyme cleaves angiotensin-converting enzyme 2 (EC 3.4.17.23) and
CA   cleaves influenzea A and B virus and coronavirus spike glycoproteins at
CA   arginine residues.
CC   -!- The enzyme, present in mammalia, cleaves and inactivates EC 3.4.17.23
CC       at arginine residues in the region R697 to R716, which enhances
CC       influenza and coronavirus uptake.
CC   -!- The enzyme also cleaves and activates influenza and coronavirus spike
CC       glycoproteins and thus facilitates virus-cell membrane fusions.
CC   -!- The cleavage of SARS-COV2 spike glycoprotein occurs between the S2
CC       and S2' site at SKPSKR/SFIEDL, while the cleavage of MERS-COV
CC       glycoprotein occurs at GSRSAR/SAIEDL.
DR   O15393, TMPS2_HUMAN;  Q9JIQ8, TMPS2_MOUSE;
//