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ENZYME entry: EC 3.4.21.35

Accepted Name
Tissue kallikrein.
Alternative Name(s)
Glandular kallikrein.
Kininogenin.
Reaction catalysed
Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa
Comment(s)
  • Formed from tissue prokallikrein by activation with trypsin.
  • A large number of tissue kallikrein-related sequences have been reported for rats and mice, though fewer seem to exist in other mammals.
  • The few that have been isolated and tested on substrates include mouse EC 3.4.21.54, submandibular proteinase a, epidermal growth- factor-binding protein, nerve growth factor gamma-subunit, rat tonin, submaxillary proteinases A and B, T-kininogenase, kallikreins K7 and K8.
  • The rat enzyme is unusual in liberating bradykinin directly from autologous kininogens by cleavage at two Arg-|-Xaa bonds.
  • Belongs to peptidase family S1.
  • Formerly EC 3.4.21.8.
Cross-references
PROSITEPDOC00124
BRENDA3.4.21.35
EC2PDB3.4.21.35
ExplorEnz3.4.21.35
PRIAM enzyme-specific profiles3.4.21.35
KEGG Ligand Database for Enzyme Nomenclature3.4.21.35
IUBMB Enzyme Nomenclature3.4.21.35
IntEnz3.4.21.35
MEDLINEFind literature relating to 3.4.21.35
MetaCyc3.4.21.35
Rhea expert-curated reactions3.4.21.35
UniProtKB/Swiss-Prot
P09582, ESTA_CANLF;  P15946, K1B11_MOUSE;  Q61759, K1B21_MOUSE;  
P15948, K1B22_MOUSE;  Q61754, K1B24_MOUSE;  P36369, K1B26_MOUSE;  
P00755, K1KB1_MOUSE;  P00756, K1KB3_MOUSE;  P15945, K1KB5_MOUSE;  
P07628, K1KB8_MOUSE;  P15949, K1KB9_MOUSE;  P36375, KLK10_RAT;  
P36376, KLK12_RAT;  P12322, KLK1_CAVPO;  P06870, KLK1_HUMAN;  
Q07276, KLK1_MACFA;  P15947, KLK1_MOUSE;  Q28773, KLK1_PAPHA;  
P00758, KLK1_RAT;  P12323, KLK2_CAVPO;  Q6H321, KLK2_HORSE;  
P20151, KLK2_HUMAN;  P00759, KLK2_RAT;  P15950, KLK3_RAT;  
P36374, KLK6_RAT;  P36373, KLK7_RAT;  P07647, KLK9_RAT;  
P32824, KLKR_MASNA;  P00752, KLK_PIG;  

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