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ENZYME

ENZYME entry: EC 3.4.21.35

PURL: https://purl.expasy.org/enzyme/EC/3.4.21.35
Accepted Name
tissue kallikrein
Alternative Name(s)
glandular kallikrein
kininogenin
Reaction catalysed
Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa
Comment(s)
  • Formed from tissue prokallikrein by activation with trypsin.
  • A large number of tissue kallikrein-related sequences have been reported for rats and mice, though fewer seem to exist in other mammals.
  • The few that have been isolated and tested on substrates include mouse EC 3.4.21.54, submandibular proteinase a, epidermal growth- factor-binding protein, nerve growth factor gamma-subunit, rat tonin, submaxillary proteinases A and B, T-kininogenase, kallikreins K7 and K8.
  • The rat enzyme is unusual in liberating bradykinin directly from autologous kininogens by cleavage at two Arg-|-Xaa bonds.
  • Belongs to peptidase family S1.
  • Formerly EC 3.4.21.8.
Cross-references
Rhea expert-curated reactions3.4.21.35
ExplorEnz3.4.21.35
IUBMB Enzyme Nomenclature3.4.21.35
UniProtKB/Swiss-Prot
P09582, ESTA_CANLFP15946, K1B11_MOUSEQ61759, K1B21_MOUSE
P15948, K1B22_MOUSEQ61754, K1B24_MOUSEP36369, K1B26_MOUSE
P00755, K1KB1_MOUSEP00756, K1KB3_MOUSEP15945, K1KB5_MOUSE
P07628, K1KB8_MOUSEP15949, K1KB9_MOUSEP36375, KLK10_RAT
P36376, KLK12_RATP12322, KLK1_CAVPOP06870, KLK1_HUMAN
Q07276, KLK1_MACFAP15947, KLK1_MOUSEQ28773, KLK1_PAPHA
P00758, KLK1_RATP12323, KLK2_CAVPOQ6H321, KLK2_HORSE
P20151, KLK2_HUMANP00759, KLK2_RATP15950, KLK3_RAT
P36374, KLK6_RATP36373, KLK7_RATP07647, KLK9_RAT
P32824, KLKR_MASNAP00752, KLK_PIG
BRENDA3.4.21.35
MetaCyc3.4.21.35
KEGG Ligand Database for Enzyme Nomenclature3.4.21.35
MEDLINEFind literature relating to 3.4.21.35

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