ID 3.4.21.41 DE complement subcomponent C1r. CA Selective cleavage of Lys(or Arg)-|-Ile bond in complement subcomponent CA C1s to form the active form of C1s (EC 3.4.21.42). CC -!- Activates C1s by proteolytic cleavage so that it can, in turn, CC activate C2 and C4. CC -!- Activated from proenzyme C1r in plasma by autocatalytic mechanism CC during activation of the complement system by the 'classical' route. CC -!- Belongs to peptidase family S1. DR Q8CG16, C1RA_MOUSE ; Q8CFG9, C1RB_MOUSE ; P00736, C1R_HUMAN ; DR Q4R577, C1R_MACFA ; Q5R1W3, C1R_PANTR ; Q5R544, C1R_PONAB ; //