ID 3.4.21.42 DE complement subcomponent C1s. AN C1s esterase. CA Cleavage of Arg-|-Ala bond in complement component C4 to form C4a and CA C4b, and Lys(or Arg)-|-Lys bond in complement component C2 to form C2a CA and C2b: the 'classical' pathway C3 convertase. CC -!- Activated from proenzyme C1s in plasma by the activated complement CC subcomponent C1r. CC -!- Belongs to peptidase family S1. DR Q0VCX1, C1S_BOVIN ; P09871, C1S_HUMAN ; Q69DK8, C1S_PIG ; DR Q6P6T1, C1S_RAT ; Q8CG14, CS1A_MOUSE ; Q8CFG8, CS1B_MOUSE ; //