ID 3.4.21.89 DE signal peptidase I. AN bacterial leader peptidase I. AN phage-procoat-leader peptidase. AN SPase I. CA Cleavage of hydrophobic, N-terminal signal or leader sequences from CA secreted and periplasmic proteins. CC -!- Unaffected by inhibitors of most serine peptidases, but site-directed CC mutagenesis implicates a Ser/Lys catalytic dyad in activity. CC -!- Cleaves a single bond -Ala-|-Ala- in M13 phage procoat protein, CC producing free signal peptide and coat protein. CC -!- Eukaryote signal peptidases that may have somewhat different CC specificity are known from the endoplasmic reticulum membrane and CC mitochondrial inner membrane. CC -!- Belongs to peptidase family S26. CC -!- Formerly EC 3.4.99.36. DR P41026, LEP1_BACAM ; P72660, LEP1_SYNY3 ; P41025, LEP2_BACAM ; DR P73157, LEP2_SYNY3 ; P37943, LEPP_BACNA ; Q57350, LEPQ_BACNA ; DR P28628, LEPS_BACSU ; P71013, LEPT_BACSU ; P42959, LEPU_BACSU ; DR O07560, LEPV_BACSU ; P54506, LEPW_BACSU ; O67088, LEP_AQUAE ; DR P41027, LEP_BACCL ; P42668, LEP_BACLI ; P57347, LEP_BUCAI ; DR Q8K9R0, LEP_BUCAP ; Q89AM6, LEP_BUCBP ; P00803, LEP_ECOLI ; DR P44454, LEP_HAEIN ; Q9ZLQ5, LEP_HELPJ ; O25300, LEP_HELPY ; DR O33021, LEP_MYCLE ; P9WKA0, LEP_MYCTO ; P9WKA1, LEP_MYCTU ; DR Q51876, LEP_PHOLA ; Q9I5G7, LEP_PSEAE ; P26844, LEP_PSEFL ; DR A8GM78, LEP_RICAH ; A8GYE1, LEP_RICB8 ; Q1RHA1, LEP_RICBR ; DR A8EXI2, LEP_RICCK ; Q92JB1, LEP_RICCN ; Q4UKA7, LEP_RICFE ; DR A8F0M1, LEP_RICM5 ; Q9ZE32, LEP_RICPR ; A8GQT7, LEP_RICRS ; DR Q8L2J7, LEP_RICTY ; P0A1W3, LEP_SALTI ; P0A1W2, LEP_SALTY ; DR Q5HHB9, LEP_STAAC ; P0A067, LEP_STAAM ; P0A068, LEP_STAAN ; DR Q6GIC3, LEP_STAAR ; Q6GAW1, LEP_STAAS ; P0A070, LEP_STAAU ; DR P0A069, LEP_STAAW ; O07344, LEP_STRPN ; P59662, LEP_STRR6 ; DR Q8H0W1, PLSP1_ARATH; P67810, SC11A_BOVIN; P67811, SC11A_CANLF; DR P67812, SC11A_HUMAN; Q9R0P6, SC11A_MOUSE; Q5R9C7, SC11A_PONAB; DR P42667, SC11A_RAT ; P0C7V7, SC11B_HUMAN; P13679, SC11C_CANLF; DR Q9BY50, SC11C_HUMAN; Q9D8V7, SC11C_MOUSE; Q5RC30, SC11C_PONAB; DR Q9WTR7, SC11C_RAT ; F0UDD2, SEC11_AJEC8; C0NKT8, SEC11_AJECG; DR C6HB29, SEC11_AJECH; A6QX24, SEC11_AJECN; C5G8L5, SEC11_AJEDR; DR D4ALL0, SEC11_ARTBC; E4V4X0, SEC11_ARTGP; C5FQ45, SEC11_ARTOC; DR A1CL29, SEC11_ASPCL; B0XWT3, SEC11_ASPFC; Q4WYF4, SEC11_ASPFU; DR Q2UBW3, SEC11_ASPOR; Q0CQC5, SEC11_ASPTN; C5JJG5, SEC11_BLAGS; DR Q5A869, SEC11_CANAL; C4YNJ0, SEC11_CANAW; B9WKT4, SEC11_CANDC; DR C5M4J6, SEC11_CANTT; Q2H1P3, SEC11_CHAGB; C4Y3D4, SEC11_CLAL4; DR C5PA33, SEC11_COCP7; E9CXH2, SEC11_COCPS; E3QXY4, SEC11_COLGM; DR Q6BP15, SEC11_DEBHA; Q86JD4, SEC11_DICDI; Q5B8K4, SEC11_EMENI; DR Q759W4, SEC11_EREGS; C7ZHK5, SEC11_FUSV7; F0XJH4, SEC11_GROCL; DR Q6CMR5, SEC11_KLULA; C4QXP7, SEC11_KOMPG; B0D4L0, SEC11_LACBS; DR C5DDH1, SEC11_LACTC; E5A8D2, SEC11_LEPMJ; A5DS09, SEC11_LODEL; DR E9E796, SEC11_METAQ; E9F8V9, SEC11_METRA; A1D6D8, SEC11_NEOFI; DR Q7RY44, SEC11_NEUCR; E7R7C4, SEC11_OGAPD; C1GU90, SEC11_PARBA; DR C1FYD2, SEC11_PARBD; C0S3S0, SEC11_PARBP; B6HC89, SEC11_PENRW; DR A5DIZ8, SEC11_PICGU; A3LXS1, SEC11_PICST; Q8IE14, SEC11_PLAF7; DR B2B3T2, SEC11_PODAN; A4RGA1, SEC11_PYRO7; B2WEL2, SEC11_PYRTR; DR E3RR70, SEC11_PYRTT; D8Q7Q5, SEC11_SCHCM; O74323, SEC11_SCHPO; DR A7E716, SEC11_SCLS1; B6Q5G0, SEC11_TALMQ; B8M5K5, SEC11_TALSN; DR D4D5I1, SEC11_TRIVH; D5GNC3, SEC11_TUBMM; C4JYM4, SEC11_UNCRE; DR C9S8G0, SEC11_VERA1; Q6CAG9, SEC11_YARLI; B3LTI7, SEC11_YEAS1; DR C7GLT4, SEC11_YEAS2; A6ZVU2, SEC11_YEAS7; C8ZAS4, SEC11_YEAS8; DR E7KDY6, SEC11_YEASA; E7Q587, SEC11_YEASB; E7KQ01, SEC11_YEASL; DR P15367, SEC11_YEAST; E7LVX4, SEC11_YEASV; E7QG89, SEC11_YEASZ; DR C5E3W1, SEC11_ZYGRC; O04348, TPP1_ARATH ; Q9M9Z2, TPP2_ARATH ; //