ID   3.4.21.94
DE   proprotein convertase 2.
AN   NEC 2.
AN   neuroendocrine convertase 2.
AN   PC2.
AN   prohormone convertase II.
CA   Release of protein hormones and neuropeptides from their precursors,
CA   generally by hydrolysis of -Lys-Arg-|- bonds.
CC   -!- A calcium dependent enzyme, maximally active at about pH 5.5.
CC   -!- Specificity is broader than that of prohormone convertase 1.
CC   -!- Substrates include pro-opiomelanocortin, proenkephalin, prodynorphin,
CC       proinsulin and proluteinizing-hormone-releasing hormone.
CC   -!- Unlike prohormone convertase 1, does not cleave prorenin or
CC       prosomatostatin.
CC   -!- Usually processing of prodynorphin occurs at a bond in which P2 is
CC       Thr.
CC   -!- Present in the regulated secretory pathway of neuroendocrine cells,
CC       commonly actin co-operatively with prohormone convertase 1.
CC   -!- Belongs to peptidase family S8.
DR   Q9GLR0, NEC2_BOVIN ;  G5ECN9, NEC2_CAEEL ;  Q9VBC7, NEC2_DROME ;
DR   P16519, NEC2_HUMAN ;  P21661, NEC2_MOUSE ;  Q03333, NEC2_PIG   ;
DR   Q5REC2, NEC2_PONAB ;  P28841, NEC2_RAT   ;
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