Expasy logo

ENZYME

ENZYME entry: EC 3.4.22.15

PURL: https://purl.expasy.org/enzyme/EC/3.4.22.15
Accepted Name
cathepsin L
Reaction catalysed
Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity toward protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity
Comment(s)
  • A lysosomal enzyme that is readily inhibited by the diazomethane inhibitor Z-Phe-Phe-CHN2 or the epoxide inhibitor E-64.
  • Belongs to peptidase family C1.
Cross-references
Rhea expert-curated reactions3.4.22.15
ExplorEnz3.4.22.15
IUBMB Enzyme Nomenclature3.4.22.15
UniProtKB/Swiss-Prot
P25975, CATL1_BOVINQ9GL24, CATL1_CANLFP09648, CATL1_CHICK
Q9GKL8, CATL1_CHLAEQ95029, CATL1_DROMEQ09093, CATL1_FASHE
P25773, CATL1_FELCAP07711, CATL1_HUMANP06797, CATL1_MOUSE
Q94714, CATL1_PARTEQ28944, CATL1_PIGP07154, CATL1_RAT
Q10991, CATL1_SHEEPP80342, CATL2_FASHEA0E358, CATL2_PARTE
P80532, CATL3_FASHEQ94715, CATL3_PARTEA0A1S4F2V5, CATL_AEDAE
O17473, CATL_BRUPAQ26636, CATL_SARPEQ26534, CATL_SCHMA
O45734, CPL1_CAEEL
BRENDA3.4.22.15
MetaCyc3.4.22.15
KEGG Ligand Database for Enzyme Nomenclature3.4.22.15
EC2PDB3.4.22.15
MEDLINEFind literature relating to 3.4.22.15

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.22.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-