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ENZYME

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ENZYME entry: EC 3.4.22.15

Accepted Name
cathepsin L
Reaction catalysed
Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity toward protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity
Comment(s)
  • A lysosomal enzyme that is readily inhibited by the diazomethane inhibitor Z-Phe-Phe-CHN2 or the epoxide inhibitor E-64.
  • Belongs to peptidase family C1.
Cross-references
BRENDA3.4.22.15
EC2PDB3.4.22.15
ExplorEnz3.4.22.15
PRIAM enzyme-specific profiles3.4.22.15
KEGG Ligand Database for Enzyme Nomenclature3.4.22.15
IUBMB Enzyme Nomenclature3.4.22.15
IntEnz3.4.22.15
MEDLINEFind literature relating to 3.4.22.15
MetaCyc3.4.22.15
Rhea expert-curated reactions3.4.22.15
UniProtKB/Swiss-Prot
P25975, CATL1_BOVINQ9GL24, CATL1_CANLFP09648, CATL1_CHICK
Q9GKL8, CATL1_CHLAEQ09093, CATL1_FASHEP25773, CATL1_FELCA
P07711, CATL1_HUMANP06797, CATL1_MOUSEQ94714, CATL1_PARTE
Q28944, CATL1_PIGP07154, CATL1_RATQ10991, CATL1_SHEEP
P80342, CATL2_FASHEA0E358, CATL2_PARTEP80532, CATL3_FASHE
Q94715, CATL3_PARTEO17473, CATL_BRUPAQ95029, CATL_DROME
Q26636, CATL_SARPEQ26534, CATL_SCHMAO45734, CPL1_CAEEL

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.22.-
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