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ENZYME entry: EC 3.4.22.2

Accepted Name
Papain.
Alternative Name(s)
Papaya peptidase I.
Reaction catalysed
Hydrolysis of proteins with broad specificity for peptide bonds, but preference for an amino acid bearing a large hydrophobic side chain at the P2 position. Does not accept Val in P1'
Comment(s)
  • From latex of the papaya (Carica papaya).
  • Inhibited by compound E-64 and proteins of the cystatin family.
  • Belongs to peptidase family C1.
  • Formerly EC 3.4.4.10.
Cross-references
PROSITEPDOC00126
BRENDA3.4.22.2
EC2PDB3.4.22.2
ExplorEnz3.4.22.2
PRIAM enzyme-specific profiles3.4.22.2
KEGG Ligand Database for Enzyme Nomenclature3.4.22.2
IUBMB Enzyme Nomenclature3.4.22.2
IntEnz3.4.22.2
MEDLINEFind literature relating to 3.4.22.2
MetaCyc3.4.22.2
Rhea expert-curated reactions3.4.22.2
UniProtKB/Swiss-Prot
P00784, PAPA1_CARPA

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