A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 3.4.22.27

Accepted Name
Cathepsin S.
Reaction catalysed
Similar to cathepsin L, but with much less activity on Z-Phe-Arg-|-NHMec, and more activity on the Z-Val-Val-Arg-|-Xaa compound
Comment(s)
  • A lysosomal cysteine endopeptidase that is unusual among such enzymes for its stability to neutral pH.
  • Belongs to peptidase family C1.
Cross-references
PROSITEPDOC00126
BRENDA3.4.22.27
EC2PDB3.4.22.27
ExplorEnz3.4.22.27
PRIAM enzyme-specific profiles3.4.22.27
KEGG Ligand Database for Enzyme Nomenclature3.4.22.27
IUBMB Enzyme Nomenclature3.4.22.27
IntEnz3.4.22.27
MEDLINEFind literature relating to 3.4.22.27
MetaCyc3.4.22.27
UniProtKB/Swiss-Prot
P25326, CATS_BOVIN;  Q8HY81, CATS_CANLF;  P25774, CATS_HUMAN;  
O70370, CATS_MOUSE;  Q02765, CATS_RAT;  Q8HY82, CATS_SAIBB;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.22.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.-.-
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