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ENZYME

ENZYME entry: EC 3.4.22.28

PURL: https://purl.expasy.org/enzyme/EC/3.4.22.28
Accepted Name
picornain 3C
Alternative Name(s)
foot-and-mouth protease 3C
picornavirus endopeptidase 3C
poliovirus protease 3C
rhinovirus protease 3C
Reaction catalysed
Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly
Comment(s)
  • From entero-, rhino-, aphto- and cardioviruses.
  • Larger than the homologous virus picornain 2A.
  • Belongs to peptidase family C3.
Cross-references
BRENDA3.4.22.28
EC2PDB3.4.22.28
ExplorEnz3.4.22.28
KEGG Ligand Database for Enzyme Nomenclature3.4.22.28
IUBMB Enzyme Nomenclature3.4.22.28
MEDLINEFind literature relating to 3.4.22.28
MetaCyc3.4.22.28
Rhea expert-curated reactions3.4.22.28
UniProtKB/Swiss-Prot
Q9YLS4, POLG_AEVCAQ6WQ42, POLG_AEVL2Q6R325, POLG_AEVVR
O91464, POLG_AIVA8P12915, POLG_BOVEVB8XTP8, POLG_COSAA
Q65900, POLG_CX16GQ9QF31, POLG_CX16TP22055, POLG_CXA21
P36290, POLG_CXA24P21404, POLG_CXA9P08291, POLG_CXB1J
Q9YLG5, POLG_CXB2OP03313, POLG_CXB3NQ66282, POLG_CXB3W
Q86887, POLG_CXB4EP08292, POLG_CXB4JQ03053, POLG_CXB5P
Q9QL88, POLG_CXB6SO91734, POLG_EC01FQ9YLJ1, POLG_EC05N
Q66474, POLG_EC06CQ66577, POLG_EC09BQ66849, POLG_EC09H
P29813, POLG_EC11GQ66575, POLG_EC12TQ9WN78, POLG_EC30B
P08490, POLG_ECHO9P03304, POLG_EMCVP17593, POLG_EMCVB
P17594, POLG_EMCVDQ66765, POLG_EMCVRP12296, POLG_ENMGO
A2I7M2, POLG_FMDA1Q9Q2N9, POLG_FMDS2P03306, POLG_FMDV1
P03307, POLG_FMDV5P03308, POLG_FMDVAP03309, POLG_FMDVC
P03310, POLG_FMDVIP03305, POLG_FMDVOQ6PMV1, POLG_FMDVP
P03311, POLG_FMDVSP15072, POLG_FMDVTP49303, POLG_FMDVZ
Q8V0N6, POLG_HAV88Q5Y944, POLG_HAVCFQ67825, POLG_HAVGB
A3FMB2, POLG_HAVH2Q05794, POLG_HAVHAP08617, POLG_HAVHM
A5LGW7, POLG_HAVJ8P06441, POLG_HAVLAP13901, POLG_HAVMB
Q9DWR1, POLG_HAVNOP14553, POLG_HAVS2P32537, POLG_HE701
B9VUU3, POLG_HE71Q66478, POLG_HE71BQ66479, POLG_HE71M
Q68T42, POLG_HED68C6KEF6, POLG_HKV1Q66578, POLG_HPE1H
O73556, POLG_HPE2WQ9YID8, POLG_HPEV5P03303, POLG_HRV14
E5D8F2, POLG_HRV15Q82122, POLG_HRV16P23008, POLG_HRV1A
P12916, POLG_HRV1BP04936, POLG_HRV2Q82081, POLG_HRV3
P07210, POLG_HRV8AQ8JV21, POLG_LJUV1O41174, POLG_PEV9U
P03300, POLG_POL1MP03301, POLG_POL1SP06210, POLG_POL2L
P23069, POLG_POL2WP06209, POLG_POL32P03302, POLG_POL3L
C0MHL9, POLG_SAFVC5MSH2, POLG_SALVAP16604, POLG_SVDVH
P13900, POLG_SVDVUQ155Z9, POLG_SVV1P08544, POLG_TMEVB
P13899, POLG_TMEVDP08545, POLG_TMEVG

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.22.-
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