ENZYME entry: EC 3.4.22.38
Accepted Name |
cathepsin K.
|
Alternative Name(s) |
cathepsin O. |
cathepsin O2. |
cathepsin X. |
Reaction catalysed |
Broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg |
Comment(s) |
- Prominently expressed in mammalian osteoclasts, and believed to play
a role in bone resorption.
- Belongs to peptidase family C1.
|
Cross-references |
BRENDA | 3.4.22.38 |
EC2PDB | 3.4.22.38 |
ExplorEnz | 3.4.22.38 |
PRIAM enzyme-specific profiles | 3.4.22.38 |
KEGG Ligand Database for Enzyme Nomenclature | 3.4.22.38 |
IUBMB Enzyme Nomenclature | 3.4.22.38 |
IntEnz | 3.4.22.38 |
MEDLINE | Find literature relating to 3.4.22.38 |
MetaCyc | 3.4.22.38 |
Rhea expert-curated reactions | 3.4.22.38 |
UniProtKB/Swiss-Prot |
Q5E968, CATK_BOVIN; | Q3ZKN1, CATK_CANLF; | Q90686, CATK_CHICK; |
P43235, CATK_HUMAN; | P61276, CATK_MACFA; | P61277, CATK_MACMU; |
P55097, CATK_MOUSE; | Q9GLE3, CATK_PIG; | P43236, CATK_RABIT; |
O35186, CATK_RAT; |
|
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