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ENZYME entry: EC 3.4.22.38

Accepted Name
Cathepsin K.
Alternative Name(s)
Cathepsin O.
Cathepsin O2.
Cathepsin X.
Reaction catalysed
Broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg
Comment(s)
  • Prominently expressed in mammalian osteoclasts, and believed to play a role in bone resorption.
  • Belongs to peptidase family C1.
Cross-references
PROSITEPDOC00126
BRENDA3.4.22.38
EC2PDB3.4.22.38
ExplorEnz3.4.22.38
PRIAM enzyme-specific profiles3.4.22.38
KEGG Ligand Database for Enzyme Nomenclature3.4.22.38
IUBMB Enzyme Nomenclature3.4.22.38
IntEnz3.4.22.38
MEDLINEFind literature relating to 3.4.22.38
MetaCyc3.4.22.38
UniProtKB/Swiss-Prot
Q5E968, CATK_BOVIN;  Q3ZKN1, CATK_CANLF;  Q90686, CATK_CHICK;  
P43235, CATK_HUMAN;  P61276, CATK_MACFA;  P61277, CATK_MACMU;  
P55097, CATK_MOUSE;  Q9GLE3, CATK_PIG;  P43236, CATK_RABIT;  
O35186, CATK_RAT;  

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