ENZYME entry: EC 3.4.22.38
| Accepted Name |
|---|
| Cathepsin K.
|
| Alternative Name(s) |
|---|
| Cathepsin O. |
| Cathepsin O2. |
| Cathepsin X. |
| Reaction catalysed |
|---|
| Broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg |
| Comment(s) |
|---|
- Prominently expressed in mammalian osteoclasts, and believed to play
a role in bone resorption.
- Belongs to peptidase family C1.
|
| Cross-references |
|---|
| PROSITE | PDOC00126 |
| BRENDA | 3.4.22.38 |
| EC2PDB | 3.4.22.38 |
| ExplorEnz | 3.4.22.38 |
| PRIAM enzyme-specific profiles | 3.4.22.38 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.4.22.38 |
| IUBMB Enzyme Nomenclature | 3.4.22.38 |
| IntEnz | 3.4.22.38 |
| MEDLINE | Find literature relating to 3.4.22.38 |
| MetaCyc | 3.4.22.38 |
| UniProtKB/Swiss-Prot |
| Q5E968, CATK_BOVIN; | Q3ZKN1, CATK_CANLF; | Q90686, CATK_CHICK; |
| P43235, CATK_HUMAN; | P61276, CATK_MACFA; | P61277, CATK_MACMU; |
| P55097, CATK_MOUSE; | Q9GLE3, CATK_PIG; | P43236, CATK_RABIT; |
| O35186, CATK_RAT; |
|
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