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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 3.4.22.43

Accepted Name
Cathepsin V.
Alternative Name(s)
Cathepsin L2.
Cathepsin U.
Reaction catalysed
The recombinant enzyme hydrolyzes proteins (serum albumin, collagen) and synthetic substrates (Z-Phe-Arg-NHMec > Z-Leu-Arg-NHMec > Z-Val-Arg-NHMec)
Comment(s)
  • Maximally active at pH 5.7 and unstable at neutral pH.
  • Compound E-64, leupeptin and chicken cystatin are inhibitors.
  • Belongs to peptidase family C1.
Cross-references
PROSITEPDOC00126
BRENDA3.4.22.43
EC2PDB3.4.22.43
ExplorEnz3.4.22.43
PRIAM enzyme-specific profiles3.4.22.43
KEGG Ligand Database for Enzyme Nomenclature3.4.22.43
IUBMB Enzyme Nomenclature3.4.22.43
IntEnz3.4.22.43
MEDLINEFind literature relating to 3.4.22.43
MetaCyc3.4.22.43
UniProtKB/Swiss-Prot
Q5E998, CATL2_BOVIN;  O60911, CATL2_HUMAN;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.22.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-