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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC

Accepted Name
Nuclear-inclusion-a endopeptidase.
Alternative Name(s)
Potyvirus NIa protease.
Reaction catalysed
Hydrolyzes glutaminyl bonds, and activity is further restricted by preferences for the amino acids in P6 - P1' that vary with the species of potyvirus, e.g. Glu-Xaa-Xaa-Tyr-Xaa-Gln-|-(Ser or Gly) for the enzyme from tobacco etch virus. The natural substrate is the viral polyprotein, but other proteins and oligopeptides containing the appropriate consensus sequence are also cleaved
  • The potyviruses cause diseases in plants, and inclusion bodies appear in the host cell nuclei, protein a of these being the endopeptidase.
  • The enzyme finds practical use when encoded in vectors for the artificial expression of recombinant fusion proteins, since it can confer on them the capacity for autolytic cleavage.
  • It is also reported that transgenic plants expressing the enzyme are resistant to viral infection.
  • Belongs to peptidase family C4.
PRIAM enzyme-specific profiles3.4.22.44
KEGG Ligand Database for Enzyme Nomenclature3.4.22.44
IUBMB Enzyme Nomenclature3.4.22.44
MEDLINEFind literature relating to
P90245, POL1_BAMMN;  Q04574, POL1_BAYMG;  Q01206, POL1_BAYMJ;  
Q9YJW3, POL1_BAYMY;  Q65399, POLG_BCMNN;  Q65730, POLG_BSTV1;  
P17765, POLG_BYMV;  P31999, POLG_LMV0;  P89876, POLG_LMVE;  
P20234, POLG_OMV;  Q01500, POLG_PEMVC;  O56075, POLG_PEMVM;  
P13529, POLG_PPVD;  Q01681, POLG_PPVEA;  P17766, POLG_PPVNA;  
P17767, POLG_PPVRA;  Q84934, POLG_PPVSK;  Q01901, POLG_PRSVH;  
P29152, POLG_PSBMV;  Q85197, POLG_PVMA;  Q02963, POLG_PVYHU;  
P18247, POLG_PVYN;  O11436, POLG_RGMVD;  Q90069, POLG_SBMVG;  
P21231, POLG_SBMVN;  P89201, POLG_SPMMV;  P04517, POLG_TEV;  
P09814, POLG_TVMV;  P18478, POLG_WMV2U;  P18479, POLG_ZYMVC;  
Q89330, POLG_ZYMVR;  O36979, POLG_ZYMVS;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.22.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.-.-
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