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ENZYME

ENZYME entry: EC 3.4.22.44

PURL: https://purl.expasy.org/enzyme/EC/3.4.22.44
Accepted Name
nuclear-inclusion-a endopeptidase
Alternative Name(s)
potyvirus NIa protease
Reaction catalysed
Hydrolyzes glutaminyl bonds, and activity is further restricted by preferences for the amino acids in P6 - P1' that vary with the species of potyvirus, e.g. Glu-Xaa-Xaa-Tyr-Xaa-Gln-|-(Ser or Gly) for the enzyme from tobacco etch virus. The natural substrate is the viral polyprotein, but other proteins and oligopeptides containing the appropriate consensus sequence are also cleaved
Comment(s)
  • The potyviruses cause diseases in plants, and inclusion bodies appear in the host cell nuclei, protein a of these being the endopeptidase.
  • The enzyme finds practical use when encoded in vectors for the artificial expression of recombinant fusion proteins, since it can confer on them the capacity for autolytic cleavage.
  • It is also reported that transgenic plants expressing the enzyme are resistant to viral infection.
  • Belongs to peptidase family C4.
Cross-references
BRENDA3.4.22.44
EC2PDB3.4.22.44
ExplorEnz3.4.22.44
KEGG Ligand Database for Enzyme Nomenclature3.4.22.44
IUBMB Enzyme Nomenclature3.4.22.44
MEDLINEFind literature relating to 3.4.22.44
MetaCyc3.4.22.44
Rhea expert-curated reactions3.4.22.44
UniProtKB/Swiss-Prot
P90245, POL1_BAMMNQ04574, POL1_BAYMGQ01206, POL1_BAYMJ
Q9YJW3, POL1_BAYMYQ65399, POLG_BCMNNQ65730, POLG_BSTV1
Q65729, POLG_BSTVGQ6XW15, POLG_BTMVA0AUJ5, POLG_BVY3
P17765, POLG_BYMVP31999, POLG_LMV0P89876, POLG_LMVE
P20234, POLG_OMVQ01500, POLG_PEMVCO56075, POLG_PEMVM
P13529, POLG_PPVDQ01681, POLG_PPVEAP17766, POLG_PPVNA
P17767, POLG_PPVRAQ84934, POLG_PPVSKQ01901, POLG_PRSVH
P29152, POLG_PSBMVQ85197, POLG_PVMAQ02963, POLG_PVYHU
P18247, POLG_PVYNO11436, POLG_RGMVDQ90069, POLG_SBMVG
P21231, POLG_SBMVNP89201, POLG_SPMMVP04517, POLG_TEV
A4KZ49, POLG_TRMVUP89509, POLG_TUMVJQ02597, POLG_TUMVQ
P09814, POLG_TVMVP18478, POLG_WMV2UP18479, POLG_ZYMVC
Q89330, POLG_ZYMVRO36979, POLG_ZYMVS

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