Expasy logo

ENZYME

ENZYME entry: EC 3.4.22.45

PURL: https://purl.expasy.org/enzyme/EC/3.4.22.45
Accepted Name
helper-component proteinase
Alternative Name(s)
HC-Pro
Reaction catalysed
Hydrolyzes a Gly-|-Gly bond at its own C-terminus, commonly in the sequence -Tyr-Xaa-Val-Gly-|-Gly, in the processing of the potyviral polyprotein
Comment(s)
  • Known from many potyviruses.
  • The helper component-proteinase of the tobacco etch virus is a multifunctional protein with several known activities.
  • The N-terminal region is required for aphid transmission and efficient genome amplification, the central region is required for long-distance movement in plants, and the C-terminal domain has cysteine endopeptidase activity.
  • Belongs to peptidase family C6.
Cross-references
BRENDA3.4.22.45
EC2PDB3.4.22.45
ExplorEnz3.4.22.45
KEGG Ligand Database for Enzyme Nomenclature3.4.22.45
IUBMB Enzyme Nomenclature3.4.22.45
MEDLINEFind literature relating to 3.4.22.45
MetaCyc3.4.22.45
Rhea expert-curated reactions3.4.22.45
UniProtKB/Swiss-Prot
P0CJ94, MVP_BCMNNP0CJ96, MVP_BTMVP0CJ95, MVP_BYMV
P0CJ97, MVP_LMV0P0CW79, MVP_LMVEP0CK01, MVP_PEMVC
P0CK00, MVP_PEMVMP0CK03, MVP_PPVDP0CK02, MVP_PPVNA
P0CK04, MVP_PPVSKP0CJ98, MVP_PRSVHP0CJ99, MVP_PSBMV
P0CK05, MVP_PVMAP0CK06, MVP_PVYHUP0CJ93, MVP_PVYN
P0CK07, MVP_SBMVGP0CK08, MVP_SBMVNP0CK09, MVP_TEV
P0CK11, MVP_TUMVJP0CK12, MVP_TUMVQP0CK10, MVP_TVMV
P0CK13, MVP_ZYMVCP0CK14, MVP_ZYMVRP0CK15, MVP_ZYMVS
Q65329, POL2_BAMMAP89684, POL2_BAMMNQ65657, POL2_BAMMU
Q01365, POL2_BAYMGQ01207, POL2_BAYMJQ9YJW2, POL2_BAYMY
Q65399, POLG_BCMNNQ65730, POLG_BSTV1Q6XW15, POLG_BTMV
A0AUJ5, POLG_BVY3P17765, POLG_BYMVP31999, POLG_LMV0
P89876, POLG_LMVEQ01500, POLG_PEMVCO56075, POLG_PEMVM
P13529, POLG_PPVDP17766, POLG_PPVNAP17767, POLG_PPVRA
Q84934, POLG_PPVSKQ01901, POLG_PRSVHP29152, POLG_PSBMV
Q85197, POLG_PVMAP22601, POLG_PVYCQ02963, POLG_PVYHU
P18247, POLG_PVYNP22602, POLG_PVYOO11436, POLG_RGMVD
Q90069, POLG_SBMVGP21231, POLG_SBMVNP89201, POLG_SPMMV
P04517, POLG_TEVA4KZ49, POLG_TRMVUP89509, POLG_TUMVJ
Q02597, POLG_TUMVQP09814, POLG_TVMVP18479, POLG_ZYMVC
Q89330, POLG_ZYMVRO36979, POLG_ZYMVS

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.22.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-