ID   3.4.22.46
DE   L-peptidase.
CA   Autocatalytically cleaves itself from the polyprotein of the foot-
CA   and-mouth disease virus by hydrolysis of a Lys-|-Gly bond, but then
CA   cleaves host cell initiation factor eIF-4G at bonds -Gly-|-Arg- and
CA   -Lys-|-Arg-.
CC   -!- Best known from foot-and-mouth disease virus, but occurs in other
CC       aphthoviruses and cardioviruses.
CC   -!- Destruction of initiation factor eIF-4G has the effect of shutting
CC       off host-cell protein synthesis while allowing synthesis of viral
CC       proteins to continue.
CC   -!- The tertiary structure reveals a distant relationship to papain and,
CC       consistent with this, compound E-64 is inhibitory.
CC   -!- Belongs to peptidase family C28.
DR   P03306, POLG_FMDV1 ;  P03307, POLG_FMDV5 ;  P03308, POLG_FMDVA ;
DR   P03309, POLG_FMDVC ;  P03310, POLG_FMDVI ;  P03305, POLG_FMDVO ;
DR   P03311, POLG_FMDVS ;  P15072, POLG_FMDVT ;  P49303, POLG_FMDVZ ;
//