ID   3.4.22.49
DE   separase.
AN   separin.
CA   All bonds known to be hydrolyzed by this endopeptidase have arginine in
CA   P1 and an acidic residue in P4. P6 is often occupied by an acidic residue
CA   or by a hydroxy-amino-acid residue, the phosphorylation of which enhances
CA   cleavage.
CC   -!- In both Saccharomyces cerevisiae and human cells, cleavage of the
CC       cohesin subunit Scc1 by separase is required for sister chromatid
CC       separation in mitosis.
CC   -!- S.cerevisiae separase is also known to cleave the Rec8 subunit of a
CC       meiotic cohesin complex and the kinetochore protein Slk19.
CC   -!- Belongs to peptidase family C50.
DR   P33144, BIMB_EMENI ;  P18296, CUT1_SCHPO ;  Q5IBC5, ESP1_ARATH ;
DR   Q03018, ESP1_YEAST ;  Q14674, ESPL1_HUMAN;  P60330, ESPL1_MOUSE;
DR   G5ED39, SEP1_CAEEL ;
//