A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 3.4.22.53
| Accepted Name |
|---|
| Calpain-2.
|
| Alternative Name(s) |
|---|
| Calcium-activated neutral protease II. |
| M-calpain. |
| Milli-calpain. |
| Reaction catalysed |
|---|
| Broad endopeptidase specificity |
| Cofactor(s) |
|---|
| Ca(2+).
|
| Comment(s) |
|---|
- Cytosolic in animal cells.
- The active enzyme molecule is a heterodimer in which the large
subunit contains the peptidase unit, and the small subunit is also a
component of EC 3.4.22.52.
- Belongs to peptidase family C2.
- Formerly EC 3.4.22.17 and EC 3.4.24.5.
|
| Cross-references |
|---|
| PROSITE | PDOC00126 |
| BRENDA | 3.4.22.53 |
| EC2PDB | 3.4.22.53 |
| ExplorEnz | 3.4.22.53 |
| PRIAM enzyme-specific profiles | 3.4.22.53 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.4.22.53 |
| IUBMB Enzyme Nomenclature | 3.4.22.53 |
| IntEnz | 3.4.22.53 |
| MEDLINE | Find literature relating to 3.4.22.53 |
| MetaCyc | 3.4.22.53 |
| UniProtKB/Swiss-Prot |
| Q27971, CAN2_BOVIN; | Q92178, CAN2_CHICK; | P17655, CAN2_HUMAN; |
| Q9GLG1, CAN2_MACFA; | O08529, CAN2_MOUSE; | P43367, CAN2_PIG; |
| P06814, CAN2_RABIT; | Q07009, CAN2_RAT; | A6NHC0, CAN8_HUMAN; |
| Q91VA3, CAN8_MOUSE; | Q78EJ9, CAN8_RAT; |
|
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