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ENZYME entry: EC 3.4.22.53

Accepted Name
Calpain-2.
Alternative Name(s)
Calcium-activated neutral protease II.
M-calpain.
Milli-calpain.
Reaction catalysed
Broad endopeptidase specificity
Cofactor(s)
Ca(2+).
Comment(s)
  • Cytosolic in animal cells.
  • The active enzyme molecule is a heterodimer in which the large subunit contains the peptidase unit, and the small subunit is also a component of EC 3.4.22.52.
  • Belongs to peptidase family C2.
  • Formerly EC 3.4.22.17 and EC 3.4.24.5.
Cross-references
PROSITEPDOC00126
BRENDA3.4.22.53
EC2PDB3.4.22.53
ExplorEnz3.4.22.53
PRIAM enzyme-specific profiles3.4.22.53
KEGG Ligand Database for Enzyme Nomenclature3.4.22.53
IUBMB Enzyme Nomenclature3.4.22.53
IntEnz3.4.22.53
MEDLINEFind literature relating to 3.4.22.53
MetaCyc3.4.22.53
Rhea expert-curated reactions3.4.22.53
UniProtKB/Swiss-Prot
Q27971, CAN2_BOVIN;  Q92178, CAN2_CHICK;  P17655, CAN2_HUMAN;  
Q9GLG1, CAN2_MACFA;  O08529, CAN2_MOUSE;  P43367, CAN2_PIG;  
P06814, CAN2_RABIT;  Q07009, CAN2_RAT;  A6NHC0, CAN8_HUMAN;  
Q91VA3, CAN8_MOUSE;  Q78EJ9, CAN8_RAT;  

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