ID   3.4.22.59
DE   caspase-6.
AN   apoptotic protease Mch-2.
AN   CASP-6.
AN   Mch2.
CA   Strict requirement for Asp at position P1 and has a preferred cleavage
CA   sequence of Val-Glu-His-Asp-|-.
CC   -!- Caspase-6 is an effector/executioner caspase, as are caspase-3
CC       (EC 3.4.22.56) and caspase-7 (EC 3.4.22.60).
CC   -!- These caspases are responsible for the proteolysis of the majority of
CC       cellular polypeptides, [e.g. poly(ADP-ribose) polymerase (PARP)],
CC       which lead to the apoptotic phenotype.
CC   -!- Caspase-6 can cleave its prodomain to produce mature caspase-6, which
CC       directly activates caspase-8 (EC 3.4.22.61) and leads to cytochrome c
CC       release from the mitochondria; the release of cytochrome c, which is
CC       an essential component of the intrinsic apoptosis pathway.
CC   -!- Can also cleave and inactivate lamins, the intermediate filament
CC       scaffold proteins of the nuclear envelope, leading to nuclear
CC       fragementation in the final phases of apoptosis.
CC   -!- Belongs to peptidase family C14.
DR   Q3T0P5, CASP6_BOVIN;  A0A1D5PPP7, CASP6_CHICK;  P55212, CASP6_HUMAN;
DR   O08738, CASP6_MOUSE;  O35397, CASP6_RAT  ;
//