ID   3.4.22.61
DE   caspase-8.
AN   apoptotic cysteine protease.
AN   apoptotic protease Mch-5.
AN   CAP4.
AN   CASP-8.
AN   FADD-homologous ICE/CED-3-like protease.
AN   FADD-like ICE.
AN   FLICE.
AN   ICE-like apoptotic protease 5.
AN   MACH.
AN   mammalian Ced-3 homolog 5.
AN   Mch5.
AN   MORT1-associated CED-3 homolog.
CA   Strict requirement for Asp at position P1 and has a preferred cleavage
CA   sequence of (Leu/Asp/Val)-Glu-Thr-Asp-|-(Gly/Ser/Ala).
CC   -!- Caspase-8 is an initiator caspase, as are caspase-2 (EC 3.4.22.55),
CC       caspase-9 (EC 3.4.22.62) and caspase-10 (EC 3.4.22.63).
CC   -!- Apical activator of the extrinsic (death receptor) apoptosis pathway,
CC       triggered by death receptor ligation.
CC   -!- Contains two tandem death effector domains (DEDs) in its N-terminal
CC       prodomain, which play a role in procaspase activation.
CC   -!- Linked to cell surface death receptors such as Fas.
CC   -!- When Fas is aggregated by the Fas ligand, procaspase-8 is recruited
CC       to the death receptor where it is activated.
CC   -!- Has a preference for Glu at P3 and prefers small residues, such as
CC       Gly, Ser and Ala at the P1' position.
CC   -!- Has very broad P4 specificity, tolerating substrates with Asp, Val or
CC       Leu in this position.
CC   -!- Endogenous substrates for caspase-8 include procaspase-3, the pro-
CC       apoptotic Bcl-2 family member Bid, RIP, PAK2 and the caspase-8
CC       activity modulator FLIPL.
CC   -!- Belongs to peptidase family C14.
DR   Q8IRY7, CASP8_DROME;  Q29IM7, CASP8_DROPS;  Q14790, CASP8_HUMAN;
DR   O89110, CASP8_MOUSE;  Q9JHX4, CASP8_RAT  ;
//