ID   3.4.22.62
DE   caspase-9.
AN   APAF-3.
AN   apoptotic protease-activating factor 3.
AN   apoptotic protease Mch-6.
AN   CASP-9.
AN   ICE-LAP6.
AN   ICE-like apoptotic protease 6.
CA   Strict requirement for an Asp residue at position P1 and with a marked
CA   preference for His at position P2. It has a preferred cleavage sequence
CA   of Leu-Gly-His-Asp-|-Xaa.
CC   -!- Caspase-9 is an initiator caspase, as are caspase-2 (EC 3.4.22.55),
CC       caspase-8 (EC 3.4.22.61) and caspase-10 (EC 3.4.22.63).
CC   -!- Contains a caspase-recruitment domain (CARD) in its N-terminal
CC       prodomain, which plays a role in procaspase activation.
CC   -!- An alternatively spliced version of caspase-9 also exists, caspase-
CC       9S, that inhibits apoptosis, similar to the situation found with
CC       caspase-2.
CC   -!- Phosphorylation of caspase-9 from some species by Akt, a serine-
CC       threonine protein kinase, inhibits caspase activity in vitro and
CC       caspase activation in vivo.
CC   -!- The activity of caspase-9 is increased dramatically upon association
CC       with the apoptosome but the enzyme can be activated without
CC       proteolytic cleavage.
CC   -!- Procaspase-3 is the enzyme's physiological substrate.
CC   -!- Belongs to peptidase family C14.
DR   P55211, CASP9_HUMAN;  Q8C3Q9, CASP9_MOUSE;
//