ID 3.4.22.64 DE caspase-11. AN CASP-11. CA Strict requirement for Asp at the P1 position and has a preferred CA cleavage sequence of (Ile/Leu/Val/Phe)-Gly-His-Asp-|-. CC -!- Part of the family of inflammatory-caspases, which also includes CC caspase-1 (EC 3.4.22.36), caspase-4 (EC 3.4.22.57) and caspase-5 CC (EC 3.4.22.58) in humans and caspase-12, caspase-13 and caspase-14 in CC mice. CC -!- Contains a caspase-recruitment domain (CARD) in its N-terminal CC prodomain, which plays a role in procaspase activation. CC -!- Like caspase-5, but unlike caspase-4, this enzyme can be induced by CC lipopolysaccharide. CC -!- Not only activates caspase-1, which is required for the maturation of CC proinflammatory cytokines such as interleukin-1beta (IL-1beta) and CC IL-18, but it also activates caspase-3 (EC 3.4.22.56), which leads to CC cellular apoptosis under pathological conditions. CC -!- Belongs to peptidase family C14. DR P70343, CASP4_MOUSE; //