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ENZYME entry: EC 3.4.22.65

Accepted Name
Peptidase 1 (mite).
Alternative Name(s)
Allergen Der p 1.
Endopeptidase 1 (mite).
Major mite fecal allergen Der p 1.
Reaction catalysed
Broad endopeptidase specificity
Comment(s)
  • This enzyme, derived from the house dust mite, is a major component of the allergic immune response.
  • The substrate specificity of this enzyme is not altogether clear; it cleaves the low-affinity IgE receptor CD23 at 298-Glu-|-Ser-299 and 155-Ser-|-Ser-156.
  • It also cleaves the pulmonary structural proteins occludin and claudin at Leu-|-Leu, Asp-|-Leu and at Gly-|-Thr bonds, and it can also cleave the alpha subunit of the interleukin-2 (IL-2) receptor (CD25).
  • Using a positional scanning combinatorial library, it was found that the major substrate-specificity determinant is for Ala in the P2 position.
  • The enzyme shows only a slight preference for basic amino acids in the P1 and P3 positions and a preference for aliphatic amino acids such as Ile, Pro, Val, Leu and norleucine in the P4 position.
  • Belongs to peptidase family C1.
Cross-references
BRENDA3.4.22.65
EC2PDB3.4.22.65
ExplorEnz3.4.22.65
PRIAM enzyme-specific profiles3.4.22.65
KEGG Ligand Database for Enzyme Nomenclature3.4.22.65
IUBMB Enzyme Nomenclature3.4.22.65
IntEnz3.4.22.65
MEDLINEFind literature relating to 3.4.22.65
MetaCyc3.4.22.65
Rhea expert-curated reactions3.4.22.65
UniProtKB/Swiss-Prot
P16311, PEPT1_DERFA;  P16312, PEPT1_DERMI;  P08176, PEPT1_DERPT;  
P25780, PEPT1_EURMA;  Q1EIQ3, PEPT1_PSOOV;  

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