ENZYME entry: EC 3.4.22.65
Accepted Name |
Peptidase 1 (mite).
|
Alternative Name(s) |
Allergen Der p 1. |
Endopeptidase 1 (mite). |
Major mite fecal allergen Der p 1. |
Reaction catalysed |
Broad endopeptidase specificity |
Comment(s) |
- This enzyme, derived from the house dust mite, is a major component
of the allergic immune response.
- The substrate specificity of this enzyme is not altogether clear; it
cleaves the low-affinity IgE receptor CD23 at 298-Glu-|-Ser-299 and
155-Ser-|-Ser-156.
- It also cleaves the pulmonary structural proteins occludin and
claudin at Leu-|-Leu, Asp-|-Leu and at Gly-|-Thr bonds, and it can
also cleave the alpha subunit of the interleukin-2 (IL-2) receptor
(CD25).
- Using a positional scanning combinatorial library, it was found that
the major substrate-specificity determinant is for Ala in the P2
position.
- The enzyme shows only a slight preference for basic amino acids in
the P1 and P3 positions and a preference for aliphatic amino acids
such as Ile, Pro, Val, Leu and norleucine in the P4 position.
- Belongs to peptidase family C1.
|
Cross-references |
BRENDA | 3.4.22.65 |
EC2PDB | 3.4.22.65 |
ExplorEnz | 3.4.22.65 |
PRIAM enzyme-specific profiles | 3.4.22.65 |
KEGG Ligand Database for Enzyme Nomenclature | 3.4.22.65 |
IUBMB Enzyme Nomenclature | 3.4.22.65 |
IntEnz | 3.4.22.65 |
MEDLINE | Find literature relating to 3.4.22.65 |
MetaCyc | 3.4.22.65 |
Rhea expert-curated reactions | 3.4.22.65 |
UniProtKB/Swiss-Prot |
|
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