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ENZYME

ENZYME entry: EC 3.4.22.66

Accepted Name
calicivirin
Alternative Name(s)
calicivirus 3C-like protease
calicivirus endopeptidase
calicivirus TCP
calicivirus trypsin-like cysteine protease
Camberwell virus processing peptidase
Chiba virus processing peptidase
norovirus virus processing peptidase
Norwalk virus processing peptidase
rabbit hemorrhagic disease virus 3C endopeptidase
Southampton virus processing peptidase
Reaction catalysed
Endopeptidase with a preference for cleavage when the P1 position is occupied by Glu-|-Xaa and the P1' position is occupied by Gly-|-Yaa
Comment(s)
  • Viruses that are members of the Norovirus genus (Caliciviridae family) are a major cause of epidemic acute viral gastroenteritis.
  • The non-structural proteins of these viruses are produced by proteolytic cleavage of a large precursor polyprotein, performed by a protease that is incorporated into the polyprotein.
  • Cleavage sites are apparently defined by features based on both sequence and structure since several sites in the polyprotein fulfilling the identified sequence requirements are not cleaved.
  • The presence of acidic (Asp), basic (Arg), aromatic (Tyr) or aliphatic (Leu) amino acids at the P1' position results in only minor differences in cleavage efficiency, suggesting that steric or conformational constraints may play a role in determining specificity.
  • Changes to the amino acid at the P2 position do not alter cleavage efficiency.
  • Belongs to peptidase family C37.
Cross-references
BRENDA3.4.22.66
EC2PDB3.4.22.66
ExplorEnz3.4.22.66
PRIAM enzyme-specific profiles3.4.22.66
KEGG Ligand Database for Enzyme Nomenclature3.4.22.66
IUBMB Enzyme Nomenclature3.4.22.66
IntEnz3.4.22.66
MEDLINEFind literature relating to 3.4.22.66
MetaCyc3.4.22.66
Rhea expert-curated reactions3.4.22.66
UniProtKB/Swiss-Prot
Q288N7, POLG_BECN1Q8JN60, POLG_BECNBQ8V736, POLG_CACV4
Q96725, POLG_EBHSGP27407, POLG_FCVC6P27408, POLG_FCVF4
P27409, POLG_FCVF9Q66914, POLG_FCVURP54634, POLG_LORDV
Q83883, POLG_NVN68Q9QEJ5, POLG_PESVP27411, POLG_RHDV3
Q86119, POLG_RHDVAQ89273, POLG_RHDVBP27410, POLG_RHDVF
Q86117, POLG_RHDVSP36286, POLG_SMSV1P36287, POLG_SMSV4
Q04544, POLG_SOUV3Q6XDK8, POLG_SVM10Q69014, POLG_SVM93
Q672I1, POLG_SVSAPQ9DUN3, POLG_VESVA

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