ENZYME

A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 3.4.22.66

Accepted Name

Calicivirin.

Alternative Name(s)

Calicivirus 3C-like protease.

Calicivirus endopeptidase.

Calicivirus TCP.

Calicivirus trypsin-like cysteine protease.

Camberwell virus processing peptidase.

Chiba virus processing peptidase.

Norovirus virus processing peptidase.

Norwalk virus processing peptidase.

Rabbit hemorrhagic disease virus 3C endopeptidase.

Southampton virus processing peptidase.

Reaction catalysed

Endopeptidase with a preference for cleavage when the P1 position is occupied by Glu-|-Xaa and the P1' position is occupied by Gly-|-Yaa

Comment(s)

Viruses that are members of the Norovirus genus (Caliciviridae family) are a major cause of epidemic acute viral gastroenteritis.
The nonstructural proteins of these viruses are produced by proteolytic cleavage of a large precursor polyprotein, performed by a protease that is incorporated into the polyprotein.
Cleavage sites are apparently defined by features based on both sequence and structure since several sites in the polyprotein fulfilling the identified sequence requirements are not cleaved.
The presence of acidic (Asp), basic (Arg), aromatic (Tyr) or aliphatic (Leu) amino acids at the P1' position results in only minor differences in cleavage efficiency, suggesting that steric or conformational constraints may play a role in determining specificity.
Changes to the amino acid at the P2 position do not alter cleavage efficiency.
Belongs to peptidase family C37.

Cross-references

BRENDA

EC2PDB

ExplorEnz

PRIAM enzyme-specific profiles

KEGG Ligand Database for Enzyme Nomenclature

IUBMB Enzyme Nomenclature

IntEnz

MEDLINE

MetaCyc

UniProtKB/Swiss-Prot

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