ID 3.4.22.68 DE Ulp1 peptidase. AN Smt3-protein conjugate proteinase. AN Ubl-specific protease 1. AN Ulp1. AN Ulp1 endopeptidase. AN Ulp1 protease. CA Hydrolysis of the alpha-linked peptide bond in the sequence Gly- CA Gly-|-Ala-Thr-Tyr at the C-terminal end of the small ubiquitin-like CA modifier (SUMO) propeptide, Smt3, leading to the mature form of the CA protein. A second reaction involves the cleavage of an epsilon-linked CA peptide bond between the C-terminal glycine of the mature SUMO and the CA lysine epsilon-amino group of the target protein. CC -!- The enzyme from Saccharomyces cerevisiae can also recognize small CC ubiquitin-like modifier 1 (SUMO-1) from human as a substrate in both CC SUMO-processing (alpha-linked peptide bonds) and SUMO-deconjugation CC (epsilon-linked peptide bonds) reactions. CC -!- Ulp1 has several functions, including an essential role in CC chromosomal segregation and progression of the cell cycle through the CC G2/M phase of the cell cycle. CC -!- Belongs to peptidase family C48. DR Q94F30, ESD4_ARATH ; Q02724, ULP1_YEAST ; //