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ENZYME

ENZYME entry: EC 3.4.23.16

PURL: https://purl.expasy.org/enzyme/EC/3.4.23.16
Accepted Name
HIV-1 retropepsin
Alternative Name(s)
human immunodeficiency virus type 1 protease
Reaction catalysed
Specific for a P1 residue that is hydrophobic, and P1' variable, but often Pro
Comment(s)
  • Present in human immunodeficiency virus type 1.
  • Contributes to the maturation of the viral particle, and is a target of antiviral drugs.
  • Active enzyme is a dimer of identical 11-kDa subunits.
  • Similar enzymes occur in other retroviruses.
  • Belongs to peptidase family A2.
Cross-references
BRENDA3.4.23.16
EC2PDB3.4.23.16
ExplorEnz3.4.23.16
KEGG Ligand Database for Enzyme Nomenclature3.4.23.16
IUBMB Enzyme Nomenclature3.4.23.16
MEDLINEFind literature relating to 3.4.23.16
MetaCyc3.4.23.16
Rhea expert-curated reactions3.4.23.16
UniProtKB/Swiss-Prot
O93215, POL_HV190O12158, POL_HV192O89290, POL_HV193
Q9QBY3, POL_HV196Q9QBZ9, POL_HV197O41798, POL_HV19N
P03369, POL_HV1A2Q77373, POL_HV1ANP03366, POL_HV1B1
P04587, POL_HV1B5Q73368, POL_HV1B9P03367, POL_HV1BR
P05960, POL_HV1C4P04589, POL_HV1ELQ75002, POL_HV1ET
P04585, POL_HV1H2P12498, POL_HV1J3P20875, POL_HV1JR
P0C6F2, POL_HV1LWQ9QBZ1, POL_HV1M2P04588, POL_HV1MA
P05961, POL_HV1MNQ9QBZ5, POL_HV1MPQ79666, POL_HV1MV
P12497, POL_HV1N5P18802, POL_HV1NDP20892, POL_HV1OY
P05959, POL_HV1RHQ9WC54, POL_HV1S2Q9WC63, POL_HV1S9
O89940, POL_HV1SEP24740, POL_HV1U4Q9Q720, POL_HV1V9
Q9QSR3, POL_HV1VIP35963, POL_HV1Y2Q9IDV9, POL_HV1YB
O91080, POL_HV1YFP12499, POL_HV1Z2P17283, POL_SIVCZ
Q1A249, POL_SIVEKQ02836, POL_SIVG1P22382, POL_SIVGB
P05896, POL_SIVM1P05897, POL_SIVM2Q1A267, POL_SIVMB
P12502, POL_SIVS4P19505, POL_SIVSPQ8AII1, POL_SIVTN
P27973, POL_SIVV1P27980, POL_SIVVGP05895, POL_SIVVT

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.23.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.-.-
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