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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 3.4.23.16

Accepted Name
HIV-1 retropepsin.
Alternative Name(s)
Human immunodeficiency virus type 1 protease.
Reaction catalysed
Specific for a P1 residue that is hydrophobic, and P1' variable, but often Pro
Comment(s)
  • Present in human immunodeficiency virus type 1.
  • Contributes to the maturation of the viral particle, and is a target of antiviral drugs.
  • Active enzyme is a dimer of identical 11-kDa subunits.
  • Similar enzymes occur in other retroviruses.
  • Belongs to peptidase family A2.
Cross-references
PROSITEPDOC00128
BRENDA3.4.23.16
EC2PDB3.4.23.16
ExplorEnz3.4.23.16
PRIAM enzyme-specific profiles3.4.23.16
KEGG Ligand Database for Enzyme Nomenclature3.4.23.16
IUBMB Enzyme Nomenclature3.4.23.16
IntEnz3.4.23.16
MEDLINEFind literature relating to 3.4.23.16
MetaCyc3.4.23.16
UniProtKB/Swiss-Prot
O93215, POL_HV190;  O12158, POL_HV192;  O89290, POL_HV193;  
Q9QBY3, POL_HV196;  Q9QBZ9, POL_HV197;  O41798, POL_HV19N;  
P03369, POL_HV1A2;  Q77373, POL_HV1AN;  P03366, POL_HV1B1;  
P04587, POL_HV1B5;  Q73368, POL_HV1B9;  P03367, POL_HV1BR;  
P05960, POL_HV1C4;  P04589, POL_HV1EL;  Q75002, POL_HV1ET;  
P04585, POL_HV1H2;  P12498, POL_HV1J3;  P20875, POL_HV1JR;  
P0C6F2, POL_HV1LW;  Q9QBZ1, POL_HV1M2;  P04588, POL_HV1MA;  
P05961, POL_HV1MN;  Q9QBZ5, POL_HV1MP;  Q79666, POL_HV1MV;  
P12497, POL_HV1N5;  P18802, POL_HV1ND;  P20892, POL_HV1OY;  
P05959, POL_HV1RH;  Q9WC54, POL_HV1S2;  Q9WC63, POL_HV1S9;  
O89940, POL_HV1SE;  P24740, POL_HV1U4;  Q9Q720, POL_HV1V9;  
Q9QSR3, POL_HV1VI;  P35963, POL_HV1Y2;  Q9IDV9, POL_HV1YB;  
O91080, POL_HV1YF;  P12499, POL_HV1Z2;  P17283, POL_SIVCZ;  
Q1A249, POL_SIVEK;  Q02836, POL_SIVG1;  P22382, POL_SIVGB;  
P05896, POL_SIVM1;  Q1A267, POL_SIVMB;  P05897, POL_SIVMK;  
P12502, POL_SIVS4;  P19505, POL_SIVSP;  Q8AII1, POL_SIVTN;  
P27973, POL_SIVV1;  P27980, POL_SIVVG;  P05895, POL_SIVVT;  

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