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ENZYME entry: EC 3.4.23.20

Accepted Name
Penicillopepsin.
Alternative Name(s)
Penicillium janthinellum aspartic protease.
Peptidase A.
Reaction catalysed
Hydrolysis of proteins with broad specificity similar to that of pepsin A, preferring hydrophobic residues at P1 and P1', but also cleaving 20-Gly-|-Glu-21 in the B chain of insulin. Clots milk, and activates trypsinogen
Comment(s)
  • From the imperfect fungus Penicillium janthinellum.
  • Closely related enzymes have been isolated from P.roqueforti and P.duponti.
  • Belongs to peptidase family A1.
  • Formerly EC 3.4.4.17, EC 3.4.23.6 and EC 3.4.23.7.
Cross-references
PROSITEPDOC00128
BRENDA3.4.23.20
EC2PDB3.4.23.20
ExplorEnz3.4.23.20
PRIAM enzyme-specific profiles3.4.23.20
KEGG Ligand Database for Enzyme Nomenclature3.4.23.20
IUBMB Enzyme Nomenclature3.4.23.20
IntEnz3.4.23.20
MEDLINEFind literature relating to 3.4.23.20
MetaCyc3.4.23.20
Rhea expert-curated reactions3.4.23.20
UniProtKB/Swiss-Prot
P00798, PEPA1_PENJA;  P78735, PEPA2_PENJA;  Q9HEZ3, PEPA3_PENJA;  
Q01972, PEPA_PENRO;  B6HL60, PEPA_PENRW;  B8MF81, PEPA_TALSN;  

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