ENZYME

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ENZYME entry: EC 3.4.23.21

Accepted Name

Rhizopuspepsin.

Alternative Name(s)

Rhizopus aspartic proteinase.

Reaction catalysed

Hydrolysis of proteins with broad specificity similar to that of pepsin A, preferring hydrophobic residues at P1 and P1'. Clots milk and activates trypsinogen. Does not cleave 4-Gln-|-His-5, but does cleave 10-His-|-Leu-11 and 12-Val-|-Glu-13 in B chain of insulin

Comment(s)

From the zygomycete fungi Rhizopus chinensis and R.niveus.
Belongs to peptidase family A1.
Formerly EC 3.4.4.17, EC 3.4.23.6, EC 3.4.23.9 and EC 3.4.99.25.

Cross-references

PROSITE

BRENDA

EC2PDB

ExplorEnz

PRIAM enzyme-specific profiles

3.4.23.21

KEGG Ligand Database for Enzyme Nomenclature

3.4.23.21

IUBMB Enzyme Nomenclature

3.4.23.21

IntEnz

3.4.23.21

MEDLINE

Find literature relating to 3.4.23.21

MetaCyc

3.4.23.21

Rhea expert-curated reactions

3.4.23.21

UniProtKB/Swiss-Prot

P10602, CARP1_RHINI;	P43231, CARP2_RHINI;	Q03699, CARP3_RHINI;
Q03700, CARP4_RHINI;	P43232, CARP5_RHINI;	C0HLM4, CARP_RHIAZ;
P06026, CARP_RHICH;

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