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ENZYME entry: EC 3.4.23.3

Accepted Name
Gastricsin.
Alternative Name(s)
Pepsin C.
Reaction catalysed
More restricted specificity than pepsin A, but shows preferential cleavage at Tyr-|-Xaa bonds. High activity on hemoglobin
Comment(s)
  • Formed from progastricsin, apparently in the gastric juice of most vertebrates.
  • In addition to the fundus, progastricsin is also secreted in antrum and proximal duodenum.
  • Seminal plasma contains a zymogen that is immunologically identical with progastricsin.
  • Belongs to peptidase family A1.
  • Formerly EC 3.4.4.22.
Cross-references
PROSITEPDOC00128
BRENDA3.4.23.3
EC2PDB3.4.23.3
ExplorEnz3.4.23.3
PRIAM enzyme-specific profiles3.4.23.3
KEGG Ligand Database for Enzyme Nomenclature3.4.23.3
IUBMB Enzyme Nomenclature3.4.23.3
IntEnz3.4.23.3
MEDLINEFind literature relating to 3.4.23.3
MetaCyc3.4.23.3
Rhea expert-curated reactions3.4.23.3
UniProtKB/Swiss-Prot
Q9N2D3, PEPC_CALJA;  Q64411, PEPC_CAVPO;  P20142, PEPC_HUMAN;  
P03955, PEPC_MACFU;  Q9D7R7, PEPC_MOUSE;  P30879, PEPC_PIG;  
Q9GMY2, PEPC_RABIT;  P04073, PEPC_RAT;  Q9GMY3, PEPC_RHIFE;  
Q9GMY4, PEPC_SORUN;  P81498, PEPC_SUNMU;  

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